Results 311 to 320 of about 462,684 (373)

Exploring the therapeutic potential of H1-antihistamines in endometriosis-A gene regulation-based perspective. [PDF]

Front Med (Lausanne)
Mantha KB, Gajendran MK.
europepmc   +1 more source

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

Advanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji, Yongli Ye, Jiadi Sun, Lina Sheng, Jinyou Li, Jin Yang, Bing Wu, Yuting Wang, Xingxing Gao, Liang Luo, Jianfeng Ping, Yinzhi Zhang, Xiulan Sun   +12 more
wiley   +1 more source

PTEN/PKM2/ERα-Driven Glyoxalase 1 Overexpression Sustains PC3 Prostate Cancer Cell Growth Through MG-H1/RAGE Pathway Desensitization Leading to H₂O₂-Dependent KRIT1 Downregulation. [PDF]

Antioxidants (Basel)
Manfredelli D, Torcoli C, Pariano M, Bellezza G, Baroni T, Talesa VN, Sidoni A, Antognelli C.   +7 more
europepmc   +1 more source

Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis

Advanced Science, EarlyView.
This study identifies fatty acid desaturase 2 (FADS2) as a key regulator linking polyunsaturated fatty acid (PUFA) metabolism to psoriatic inflammation. FADS2 deficiency impairs docosahexaenoic acid (DHA) biosynthesis, enhances NF‐κB signaling, and promotes neutrophil‐driven skin inflammation. PPARα transcriptionally activates FADS2, and its activation
Jiangluyi Cai, Xue Zhou, Yu Zhuang, Lian Cui, Rui Ma, Youdong Chen, Nan Yang, Qianyu Chen, Yuanyuan Wang, Peiyao Zhu, Lingling Yao, Qian Yu, Xiaomin She, Xuyang Zhou, Yuemeng Huang, Zengyang Yu, Xilin Zhang, Jiajing Lu, Yuling Shi, Chunyuan Guo   +19 more
wiley   +1 more source

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. [PDF]

Transl Psychiatry
Perzel Mandell KA, Simmons SK, Nadig A, Farsi Z, Huang WC, Aryal S, Kwon MJ, Song B, Brenner K, Shepard N, Nicolella AA, O'Brien LD, Lichtman AH, Levin JZ, Sheng M.   +14 more
europepmc   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

The dynamic role of TRIM8, a novel ciliary protein, during various stages of mitosis. [PDF]

Cell Death Dis
Bhaduri U, Di Venere E, Squeo GM, Gemma G, Tamiro F, Avolio R, Senatore E, Salvemini L, Di Paola R, Licastro D, Iacobucci I, Tretola V, Salerno P, Feliciello A, Monti M, Giambra V, Merla G.   +16 more
europepmc   +1 more source

Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons [PDF]

Ching‐Chi Chiu, Ying‐Ling Chen, Yi‐Hsin Weng, Shu-Yu Liu, Hon-Lun Li, Tu‐Hsueh Yeh, Hung‐Li Wang   +6 more
openalex   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Transcriptomic Analysis of the Rainbow Trout Response to Single and Co-Infections with <i>Myxobolus cerebralis</i> and <i>Tetracapsuloides bryosalmonae</i> at Sites of Parasite Entry. [PDF]

Int J Mol Sci
Akram N, Ertl R, Ghanei-Motlagh R, Secombes CJ, El-Matbouli M, Holzer AS, Saleh M.   +6 more
europepmc   +1 more source