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Upregulated and Downregulated Proteins in Hepatocellular Carcinoma: A Systematic Review of Proteomic Profiling Studies

OMICS: A Journal of Integrative Biology, 2011
Abstract Hepatocellular carcinoma (HCC) has been a major clinical challenge due to low early diagnosis rate and poor prognosis. The aim of this systematic review was to identify differentially expressed proteins as potential high-confidence biomarkers for HCC, by validating data on differentially expressed proteins reported by studies
Zhihua, Liu   +3 more
openaire   +2 more sources

Upregulated p27kip1 can Downregulate Survivin Expression and Inhibit Telomerase Activity in Gastric Carcinoma Cells

Cancer Investigation, 2009
Previous study indicated that p27kip1 gene transfer can obviously inhibit the growth of some carcinoma cells. The purpose of this study was to investigate anticarcinoma mechanism of p27kip1. Gastric carcinoma cell strain SGC-7901 was transfected with recombinant adenovirus vector carrying human p27kip1 gene (Ad-p27kip1).
Weiguo, Zhang   +5 more
openaire   +2 more sources

Application of antimicrobial polypeptide host defenses to aquaculture: Exploitation of downregulation and upregulation responses

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2011
Antimicrobial polypeptides (AMPPs), consisting of peptides and small proteins with antimicrobial activity, are an integral component of innate immunity. Their often potent properties and widespread prevalence in fish suggests that designing means of manipulating their levels has considerable potential for maintaining or improving fish health.
Edward J, Noga   +3 more
openaire   +2 more sources

Upregulation of developmentally-downregulated miR-1247-5p promotes neuroprotection and axon regeneration in vivo

Neuroscience Letters
Numerous micro-RNAs (miRNAs) affect neurodevelopment and neuroprotection, but potential roles of many miRNAs in regulating these processes are still unknown. Here, we used the retinal ganglion cell (RGC) central nervous system (CNS) projection neuron and optic nerve crush (ONC) injury model, to optimize a mature miRNA arm-specific quantification method
Agnieszka Lukomska   +5 more
openaire   +2 more sources

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