Results 191 to 200 of about 1,189,976 (248)
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Environmental impact of antidepressants: Is a new prescription framework possible?
British Journal of Clinical Pharmacology, EarlyView.Aims Antidepressants such as venlafaxine and sertraline pose high risks to water ecosystems. As depressive disorders and other mental health conditions become increasingly prevalent worldwide, prescription and environmental presence of these pharmaceuticals continue to rise. This study explores the practical viability of a new framework for prescribing
Matilde Bianconi +5 more
wiley +1 more source
Occurrence of hepatitis B surface antigen in patients with Down's syndrome
The Turkish Journal of Pediatrics, 1977 M Yüksel +3 more
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Pediatric Clinics of North America, 1993
Down syndrome remains one of the most common causes of mental retardation. Although knowledge of pathogenesis remains incomplete, recent molecular biologic techniques have identified regions of the 21st chromosome critical for expression of the Down syndrome phenotype, and animal models have helped elucidate the origins of the neurochemical and ...
A, Hayes, M L, Batshaw
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Down syndrome remains one of the most common causes of mental retardation. Although knowledge of pathogenesis remains incomplete, recent molecular biologic techniques have identified regions of the 21st chromosome critical for expression of the Down syndrome phenotype, and animal models have helped elucidate the origins of the neurochemical and ...
A, Hayes, M L, Batshaw
openaire +2 more sources
Nursing Children and Young People, 2016
Down's syndrome is one of the most common congenital anomalies, affecting 1:1000 infants in the UK. It occurs in people of all races, and males and females are equally affected. It was named after a British doctor who is credited as the first person to describe the condition.
Doreen, Crawford, Annette, Dearmun
openaire +2 more sources
Down's syndrome is one of the most common congenital anomalies, affecting 1:1000 infants in the UK. It occurs in people of all races, and males and females are equally affected. It was named after a British doctor who is credited as the first person to describe the condition.
Doreen, Crawford, Annette, Dearmun
openaire +2 more sources
Archives of Neurology, 1971
DR. John Langdon Haydon Down (1828 to 1896) was a brilliant medical student from a distinguished family. 1 It therefore came as a surprise to his colleagues when he decided to devote his career to the study and care of the mentally retarded. Langdon Down became the first superintendent of the Earlswood Asylum for Idiots in Surrey, England, from 1858 ...
R H, Wilkins, I A, Brody
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DR. John Langdon Haydon Down (1828 to 1896) was a brilliant medical student from a distinguished family. 1 It therefore came as a surprise to his colleagues when he decided to devote his career to the study and care of the mentally retarded. Langdon Down became the first superintendent of the Earlswood Asylum for Idiots in Surrey, England, from 1858 ...
R H, Wilkins, I A, Brody
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The Lancet, 2003
The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome, and to better understand its phenotype. Research in prenatal screening and diagnosis aims to find methods to identify fetuses with Down's syndrome, and reduce or eliminate the need
Nancy J, Roizen, David, Patterson
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The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome, and to better understand its phenotype. Research in prenatal screening and diagnosis aims to find methods to identify fetuses with Down's syndrome, and reduce or eliminate the need
Nancy J, Roizen, David, Patterson
openaire +2 more sources
2019
Down syndrome (DS; Trisomy 21) is the most common chromosomal disorder in humans. It has numerous associated neurologic phenotypes including intellectual disability, sleep apnea, seizures, behavioral problems, and dementia. With improved access to medical care, people with DS are living longer than ever before. As more individuals with DS reach old age,
Michael S, Rafii +3 more
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Down syndrome (DS; Trisomy 21) is the most common chromosomal disorder in humans. It has numerous associated neurologic phenotypes including intellectual disability, sleep apnea, seizures, behavioral problems, and dementia. With improved access to medical care, people with DS are living longer than ever before. As more individuals with DS reach old age,
Michael S, Rafii +3 more
openaire +2 more sources
Down syndrome before down: A retrospect
American Journal of Medical Genetics, 2001We have attempted to identify published descriptions and reports of skeletal remains, figurines and paintings of suggested or supposed instances of Down syndrome predating John Langdon Haydon Down's initial account of the condition in 1866. A review of the ascertained material in each of these categories has not provided, in our opinion, convincing ...
J M, Berg, M, Korossy
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