Results 21 to 30 of about 1,189,976 (248)
Current Gerontology and Geriatrics Research, 2012 The initial clinical description of Down syndrome (DS) was made by Down in 1866 [1] and identified as trisomy of chromosome 21 by Lejeune et al. in 1959 [2]. DS, or trisomy 21, is one of the most common causes of intellectual disability (ID), and recent national prevalence estimates suggest that 14.47 per 10,000 live births are infants with DS, leading
Elizabeth Head +3 more
openaire +2 more sources
Prevalence of Down's Syndrome in England, 1998–2013
International Journal of Population Data Science, 2020 Introduction Disease registers and electronic health records are valuable resources for disease surveillance and research but can be limited by variation in data quality over time.
James C Doidge, PhD +4 more
doaj +1 more source
A vanishing brown lens: Interesting case findings!
TNOA Journal of Ophthalmic Science and Research, 2021 Lens absorption has been reported to be associated with uveitis, downs syndrome, morgagnian cataract and trauma. However, spontaneous absorption of hard brown lens is a rare entity.
Priyanka S Gupta
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Journal of Opioid Management, 2006 Opioids are used in clinical practice for sedation, anesthesia, and analgesia. Their effects depend on their pharmacokinetic and pharmacodynamic characteristics. The liver is the major site for the biotransformation of most opioids. The major metabolic pathway is oxidation.
F. Mafrica, FODALE, Vincenzo
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Studies of antithyroid antibodies in Down's syndrome
Arquivos de Neuro-Psiquiatria, 1978 The presence of antithyroid antibodies (antithyroglobulin and antimicrosomal) in the serum of patients with Down's syndrome and their respective mothers were studied based on data from the literature, showing a possible correlation between the presence ...
B. J. Schmidt +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Anaesthesia and postoperative analgesia in surgical neonates with or without Downs syndrome: Is it really different? [PDF]
, 2012 BackgroundReports conflict on optimal postoperative analgesic treatment in children with intellectual disability. We retrospectively compared postoperative analgesics consumption between neonates with and without Downs syndrome in relation to anaesthesia
Dijk, M. (Monique) van +14 more
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source