Results 101 to 110 of about 232,209 (289)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma

Journal of Translational Medicine
Background Skin cutaneous melanoma (SKCM) poses a significant public health challenge due to its aggressive nature and limited treatment options. To address this, the study introduces the Tumor Mutational Burden-Derived Immune lncRNA Prognostic Index ...
Gaohua Li, Tingting Wu, Heping Li, Chuzhong Wei, Yuanbo Sun, Pengcheng Gao, Xinlin Huang, Zining Liu, Jianwei Li, Yanan Wang, Guoxin Li, Lei Fan   +11 more
doaj   +1 more source

Recent developments in planet migration theory

, 2012
Planetary migration is the process by which a forming planet undergoes a drift of its semi-major axis caused by the tidal interaction with its parent protoplanetary disc.
A. Crida, A. Crida, A. Crida, A. Crida, A. Crida, A. Johansen, A. Lagrange, A. Pepliński, A. Pepliński, A. Pepliński, A. Pierens, A.L. Uribe, A.W. Howard, B.A. Ayliffe, C. Baruteau, C. Baruteau, C. Baruteau, C. Baruteau, C. Baruteau, C. Marois, C. Marois, C. Mordasini, C.D. Murray, C.E.J.M.L.J. Terquem, C.F. Gammie, D. Syer, D.G. Korycansky, D.N.C. Lin, D.N.C. Lin, D.N.C. Lin, F. Masset, F. Pepe, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, G. Bryden, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. Laughlin, G. Lesur, G.I. Ogilvie, H. Jang-Condell, H. Li, H. Tanaka, H. Zhang, H. Zhang, H.H. Klahr, J. Casoli, J. Goodman, J.B. Pollack, J.C.B. Papaloizou, K. Menou, K. Morohoshi, K.C. Schlaufman, K.J. Walsh, L.R. Doyle, M. Mayor, M.K. Lin, M.K. Lin, M.K. Lin, M.K. Lin, M.R. Bate, N.I. Shakura, N.J. Balmforth, P. Artymowicz, P. Artymowicz, P. Goldreich, P. Goldreich, P. Hellary, P.B. Ivanov, R. Dong, R.P. Nelson, R.P. Nelson, R.P. Nelson, R.R. Rafikov, R.V.E. Lovelace, S. Fromang, S. Ida, S. Ida, S. Michael, S. Paardekooper, S. Paardekooper, S.A. Balbus, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, T. Fleming, T. Muto, W. Kley, W. Kley, W. Lyra, W. Lyra, W.F. Winters, W.R. Ward, W.R. Ward, W.R. Ward, W.R. Ward, Y. Hasegawa, Z. Zhu   +109 more
core   +3 more sources

A probabilistic approach to quantifying hydrologic thresholds regulating migration of adult Atlantic salmon into spawning streams [PDF]

, 2017
Acknowledgment Data to support this study are provided by the Marine Scotland Science Freshwater Laboratory (MSS-FL) and are available for free download on line [Glover and Malcolm, 2015a, 2015b].Peer reviewedPublisher ...
Botter, G., Lazzaro, G., Soulsby, C., Tetzlaff, D.   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways

Heliyon
Background: Hypertrophic scar (HS) is a common fibrotic skin disease that occurs secondary to burns or injuries. The activation of the TGF-β signaling pathway contributes immensely to HS formation.
Junzheng Wu, Yajuan Song, Jianzhang Wang, Tong Wang, Liu Yang, Yi Shi, Baoqiang Song, Zhou Yu   +7 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Post-radiation increase in VEGF enhances glioma cell motility in vitro

Radiation Oncology, 2012
Background Glioblastoma multiforme (GBM) is among the most lethal of all human tumors, with frequent local recurrences after radiation therapy (RT). The mechanism accounting for such a recurrence pattern is unclear.
Kil Whoon, Tofilon Philip J, Camphausen Kevin   +2 more
doaj   +1 more source