Results 91 to 100 of about 179,147 (253)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Economic spillover study [PDF]

, 2005
The study examines available evidence of the linkages between the Alliance SSP area of the East Midlands and South Yorkshire. The study builds on scenario modelling conducted on behalf of the Alliance SSP using input-output analysis to approximate ...
Experian Business Strategies
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying the crucial oncogenic mechanisms of DDX56 based on a machine learning-based integration model of RNA-binding proteins

npj Precision Oncology
RNA-binding proteins (RBPs) play a fundamental role in cellular metabolism, with their disturbance leading to large-scale transcriptomic dysregulation. RBP dysregulation is highly prevalent in human cancers; however, its role in lung adenocarcinoma (LUAD)
Hui Jiang, Haotian Zheng, Xinjie Zhao, Yunzhi Xiang, Jiahao Li, Kai Wang, Guanghui Wang, Jiajun Du   +7 more
doaj   +1 more source

Experimental study and evaluation on influence of deep alluvium foundation suffusion on deformation of soil skeleton in foundation of Luding Hydropower Station

Yantu gongcheng xuebao
Suffusion of stratum ① in deep alluvium foundation of Luding Hydropower Station induces water gushing incident. Continuous migration of fine particles may induce skeleton deformation, and then it may threat the safety of Luding Dam, downstream cascade ...
JIN Wei 1, 2, QIU Ziyuan 2, ZHANG Dan 1, 2, XIANG Lei 2, YANG Linjun 3, LUO Yulong 2
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Genetic variability of wild populations of Leporinus elongatus in the São Domingos River - MS Brazil: a preliminary view on the construction of the hydroelectric plant

Semina: Ciências Agrárias, 2016
Most of the electricity used in Brazil comes from hydroelectric plants, mainly due to the great availability of its water resources. However, the construction of these plants denotes serious problems related to migration of native fish and the genetic ...
Ricardo Pereira Ribeiro, Maria del Pilar Rodriguez-Rodriguez, Darci Carlos Fornari, Gilmar Baumgartner, Dirceu Baumgartner, Felipe Pinheiro de Souza, Pedro Luiz de Castro, Angela Rocio Poveda-Parra, Elenice Souza dos Reis Goes, Nelson Mauricio Lopera-Barrero   +9 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma

Journal of Translational Medicine
Background Skin cutaneous melanoma (SKCM) poses a significant public health challenge due to its aggressive nature and limited treatment options. To address this, the study introduces the Tumor Mutational Burden-Derived Immune lncRNA Prognostic Index ...
Gaohua Li, Tingting Wu, Heping Li, Chuzhong Wei, Yuanbo Sun, Pengcheng Gao, Xinlin Huang, Zining Liu, Jianwei Li, Yanan Wang, Guoxin Li, Lei Fan   +11 more
doaj   +1 more source

Optimal Consistent Network Updates in Polynomial Time

, 2016
Software-defined networking (SDN) allows operators to control the behavior of a network by programatically managing the forwarding rules installed on switches.
Cerny, Pavol, Foster, Nate, Jagnik, Nilesh, McClurg, Jedidiah   +3 more
core   +1 more source