Results 101 to 110 of about 179,147 (253)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways

Heliyon
Background: Hypertrophic scar (HS) is a common fibrotic skin disease that occurs secondary to burns or injuries. The activation of the TGF-β signaling pathway contributes immensely to HS formation.
Junzheng Wu, Yajuan Song, Jianzhang Wang, Tong Wang, Liu Yang, Yi Shi, Baoqiang Song, Zhou Yu   +7 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. [PDF]

, 2012
Migrating cells acquire front-rear polarity with a leading edge and a trailing tail for directional movement. The Rac exchange factor Tiam1 participates in polarized cell migration with the PAR complex of PAR3, PAR6, and atypical protein kinase C ...
Collard, John G, Ginsberg, Mark H, Kaibuchi, Kozo, Kakeno, Mai, Katsumi, Akira, Kimura, Kazushi, Matsui, Toshinori, Matsuzawa, Kenji, Mizoguchi, Akira, Murase, Kiyoko, Sato, Kazuhide, Sugiyama, Ikuko, Wang, Shujie, Watanabe, Takashi, Ye, Feng   +14 more
core  

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Integrated analysis of groundwater storage dynamics and drought migration in the Tarim River Basin

Journal of Hydrology: Regional Studies
Study region: The Tarim River Basin (TRB), an arid inland river basin in northwestern China. Study focus: This study investigates groundwater drought dynamics in the TRB from 2002 to 2024 using groundwater storage anomalies (GWSA).
Jing Wang, Guotao Dong, Hongbo Ling, Na Tang, Zhe Gao   +4 more
doaj   +1 more source

Recent developments in planet migration theory

, 2012
Planetary migration is the process by which a forming planet undergoes a drift of its semi-major axis caused by the tidal interaction with its parent protoplanetary disc.
A. Crida, A. Crida, A. Crida, A. Crida, A. Crida, A. Johansen, A. Lagrange, A. Pepliński, A. Pepliński, A. Pepliński, A. Pierens, A.L. Uribe, A.W. Howard, B.A. Ayliffe, C. Baruteau, C. Baruteau, C. Baruteau, C. Baruteau, C. Baruteau, C. Marois, C. Marois, C. Mordasini, C.D. Murray, C.E.J.M.L.J. Terquem, C.F. Gammie, D. Syer, D.G. Korycansky, D.N.C. Lin, D.N.C. Lin, D.N.C. Lin, F. Masset, F. Pepe, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, F.S. Masset, G. Bryden, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. D’Angelo, G. Laughlin, G. Lesur, G.I. Ogilvie, H. Jang-Condell, H. Li, H. Tanaka, H. Zhang, H. Zhang, H.H. Klahr, J. Casoli, J. Goodman, J.B. Pollack, J.C.B. Papaloizou, K. Menou, K. Morohoshi, K.C. Schlaufman, K.J. Walsh, L.R. Doyle, M. Mayor, M.K. Lin, M.K. Lin, M.K. Lin, M.K. Lin, M.R. Bate, N.I. Shakura, N.J. Balmforth, P. Artymowicz, P. Artymowicz, P. Goldreich, P. Goldreich, P. Hellary, P.B. Ivanov, R. Dong, R.P. Nelson, R.P. Nelson, R.P. Nelson, R.R. Rafikov, R.V.E. Lovelace, S. Fromang, S. Ida, S. Ida, S. Michael, S. Paardekooper, S. Paardekooper, S.A. Balbus, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, S.J. Paardekooper, T. Fleming, T. Muto, W. Kley, W. Kley, W. Lyra, W. Lyra, W.F. Winters, W.R. Ward, W.R. Ward, W.R. Ward, W.R. Ward, Y. Hasegawa, Z. Zhu   +109 more
core   +3 more sources