Results 71 to 80 of about 179,147 (253)

Assessing the freshwater quality of a large-scale mining watershed : the need for integrated approaches [PDF]

, 2019
Water quality assessments provide essential information for protecting aquatic habitats and stakeholders downstream of mining sites. Moreover, mining companies must comply with environmental quality standards and include public participation in water ...
Arroyo, Nilton Deza, Beeckman, Eveline, De Saeyer, Nancy, De Schamphelaere, Karel, Forio, Marie Anne Eurie, Goethals, Peter, Mercado Garcia, Daniel, Sanchez Peña, Marco, Van Buggenhoudt, Cécile, Van Butsel, Jana, Wyseure, Guido   +10 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Lakes as a key species pool: multi-trophic biodiversity patterns in the river-lake continuum

Ecological Indicators
Within river-lake continua, phytoplankton, zooplankton, and fish constitute fundamental multi-trophic components sustaining ecosystem functioning. However, a comprehensive knowledge of their multi-trophic biodiversity patterns and associated driving ...
Hongxiang Li, Xuanhe Yu, Ming Chen, Shaoyun Cai, Dongjun Wang, Ruoyu Xu, Lei Jin, Cunqi Liu   +7 more
doaj   +1 more source

Mechanism of miR-186-5p Regulating PRKAA2 to Promote Ferroptosis 
in Lung Adenocarcinoma Cells

Chinese Journal of Lung Cancer, 2023
Background and objective Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer, and any change of miRNAs expression will affect the degree of target regulation, thus affecting intracellular homeostasis. This study verified that
Lu LIU, Xin GUAN, Yanqiao ZHAO, Xiaona WANG, Chonggao YIN, Qinghua LIU, Hongli LI   +6 more
doaj   +1 more source

On the horseshoe drag of a low-mass planet. I - Migration in isothermal disks

, 2009
We investigate the unsaturated horseshoe drag exerted on a low-mass planet by an isothermal gaseous disk. In the globally isothermal case, we use a formal- ism, based on the use of a Bernoulli invariant, that takes into account pressure effects, and that
Baruteau, F. S. Masset, J. Casoli, Masset, Masset, Masset, Masset, Masset, Tanaka, Ward, Ward   +10 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Linking the life stages of fish into a habitat-ecological flow assessment scheme under climate change and human activities

Ecological Indicators
It is widely recognized that climate change and human activities can alter the flow regimes and thus the fish habitats. Limited research has integrated fish habitats with swimming ability and ecological preferences of fish at various life stages to ...
Yiming Zhang, Wensheng Wang, Siyi Yu
doaj   +1 more source

Quantification of channel planform change on the lower Rangitikei River, New Zealand, 1949-2007: response to management? [PDF]

, 2010
The Rangitikei River, a large gravel‐bed wandering river located in the North Island of New Zealand, has outstanding scenic characteristics, recreational, fisheries and wildlife habitat features.
Fuller, Ian C, Richardson, Jane M.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source