Results 51 to 60 of about 179,147 (253)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Holocene Hydrological Changes Inferred from Alluvial Stream Entrenchment in North Tian Shan (Northwestern China) [PDF]

, 2004
We analyze the possible contribution of climate change or tectonics on fluvial incision from the study of a case example along the northern flank of Tian Shan.
Avouac, Jean-Philippe, Poisson, Blanche
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Environmental determinism of year to year recruitment variability of European eel in a small coastal catchment, the Frémur river, north-west France [PDF]

, 2009
The influence of environmental factors (mainly the river flow) on the year-to-year variability of European eel Anguilla anguilla fluvial recruitment in a small coastal River (north-west France) was examined.
Acou, Alcobendas, Barbin, Bardonnet, Birrel, Briand, Briand, Cargnelli, Casselman, Chen, Ciccotti, Ciccotti, Creutzberg, Daverat, Desaunay, Dutil, Edeline, Edeline, Edeline, Elie, Elie, Feunteun, Feunteun, Gandolfi, Gascuel, Gascuel, Hoyle, Ibbotson, Imbert, Jellyman, Jessop, Jonsson, Kettle, Knights, Laffaille, Laffaille, Laffaille, Laffaille, Legault, Legault, Martin, McCleave, McGovern, McKinnon, Moriarty, Mounaix, Naismith, Parsons, Ringuet, Sloane, Sorensen, Sorensen, Sorensen, Sullivan, Tesch, Tongiorgi, Tosi, Tosi, Vøllestad, Walsh, White, White   +61 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Hepatic UDP-glucuronosyltransferase enzyme activity decreased during salt acclimation of sea lamprey juveniles from Minho river basin

Frontiers in Marine Science, 2015
Sea lamprey (Petromyzon marinus L., 1758) is an anadromous species which migrates twice during its life cycle between freshwater and seawater. During downstream migration, the juveniles are subject to salinity changes ranging between 0 and 35. The aim of
Marta Candeias, Marta Candeias, Maria Lança, Ana Ferreira, Bernardo Quintella, Pedro Almeida   +5 more
doaj   +1 more source

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

Scientific Reports, 2023
Switching to normal diet (ND) is the regular therapy for high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD). Intermittent fasting (IF) is a unique treatment which may exhibits better therapeutic efficacy. Thus, we aim to investigate the
Dezhao Li, Yaoshan Dun, Dake Qi, Jeffrey W. Ripley-Gonzalez, Jie Dong, Nanjiang Zhou, Ling Qiu, Jie Zhang, Tanghao Zeng, Baiyang You, Suixin Liu   +10 more
doaj   +1 more source

A Southern Hemispheric influence on the North Atlantic through a shallow atmospheric circulation response [PDF]

, 2017
Previous research has discussed the importance of meridional migrations of the North Atlantic Subtropical High (NASH) on U.S. precipitation patterns, but the mechanisms that control these meridionial migrations are virtually unknown.
Bowerman, Adam R.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A novel index-based method associated with aquatic ecosystem for evaluating river longitudinal connectivity: A case study for cascade dams in the Yalong River, China

Ecological Indicators, 2023
Dams as crucial metrics for characterizing aquatic species diversity and river ecosystem have significant effects on river longitudinal connectivity (RLC).
Zhimin Yang, Jiuhe Bu, Zhi Li, Chunhui Li, Yunjun Yi, Xuan Wang, Qiang Liu   +6 more
doaj   +1 more source