Results 51 to 60 of about 232,209 (289)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Environmental determinism of year to year recruitment variability of European eel in a small coastal catchment, the Frémur river, north-west France [PDF]

, 2009
The influence of environmental factors (mainly the river flow) on the year-to-year variability of European eel Anguilla anguilla fluvial recruitment in a small coastal River (north-west France) was examined.
Acou, Alcobendas, Barbin, Bardonnet, Birrel, Briand, Briand, Cargnelli, Casselman, Chen, Ciccotti, Ciccotti, Creutzberg, Daverat, Desaunay, Dutil, Edeline, Edeline, Edeline, Elie, Elie, Feunteun, Feunteun, Gandolfi, Gascuel, Gascuel, Hoyle, Ibbotson, Imbert, Jellyman, Jessop, Jonsson, Kettle, Knights, Laffaille, Laffaille, Laffaille, Laffaille, Legault, Legault, Martin, McCleave, McGovern, McKinnon, Moriarty, Mounaix, Naismith, Parsons, Ringuet, Sloane, Sorensen, Sorensen, Sorensen, Sullivan, Tesch, Tongiorgi, Tosi, Tosi, Vøllestad, Walsh, White, White   +61 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

On the horseshoe drag of a low-mass planet. II Migration in adiabatic disks

, 2009
We evaluate the horseshoe drag exerted on a low-mass planet embedded in a gaseous disk, assuming the disk's flow in the coorbital region to be adiabatic.
Baruteau, Baruteau, F. S. Masset, J. Casoli, Kley, Lovelace, Masset, Masset, Masset, Masset, Tanaka, Ward, Ward   +12 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Assessing the freshwater quality of a large-scale mining watershed : the need for integrated approaches [PDF]

, 2019
Water quality assessments provide essential information for protecting aquatic habitats and stakeholders downstream of mining sites. Moreover, mining companies must comply with environmental quality standards and include public participation in water ...
Arroyo, Nilton Deza, Beeckman, Eveline, De Saeyer, Nancy, De Schamphelaere, Karel, Forio, Marie Anne Eurie, Goethals, Peter, Mercado Garcia, Daniel, Sanchez Peña, Marco, Van Buggenhoudt, Cécile, Van Butsel, Jana, Wyseure, Guido   +10 more
core   +1 more source

Hepatic UDP-glucuronosyltransferase enzyme activity decreased during salt acclimation of sea lamprey juveniles from Minho river basin

Frontiers in Marine Science, 2015
Sea lamprey (Petromyzon marinus L., 1758) is an anadromous species which migrates twice during its life cycle between freshwater and seawater. During downstream migration, the juveniles are subject to salinity changes ranging between 0 and 35. The aim of
Marta Candeias, Marta Candeias, Maria Lança, Ana Ferreira, Bernardo Quintella, Pedro Almeida   +5 more
doaj   +1 more source

A novel index-based method associated with aquatic ecosystem for evaluating river longitudinal connectivity: A case study for cascade dams in the Yalong River, China

Ecological Indicators, 2023
Dams as crucial metrics for characterizing aquatic species diversity and river ecosystem have significant effects on river longitudinal connectivity (RLC).
Zhimin Yang, Jiuhe Bu, Zhi Li, Chunhui Li, Yunjun Yi, Xuan Wang, Qiang Liu   +6 more
doaj   +1 more source