Results 141 to 150 of about 218,870 (301)

Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities

, 2012
Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible progressive dose-dependent cardiotoxicity.
Larion, Laura, NC DOCKS at East Carolina University   +1 more
core  

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +2 more sources

Safety and efficacy of combination therapy with apatinib and doxorubicin in metastatic soft tissue sarcomas: an observational study from multiple institutions

Cancer Management and Research, 2019
Zhichao Tian,1 Xin Wang,1 Zhiyong Liu,1 Jiaqiang Wang,1 Weitao Yao,1 Yao Zhao,2 Songtao Gao,3 Peng Zhang,1 Hong Ge41Department of Orthopedics, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, People’s ...
Tian Z, Wang X, Liu Z, Wang J, Yao W, Zhao Y, Gao S, Zhang P, Ge H   +8 more
doaj  

Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer

Synergistic combination therapy approach offers lots of options for delivery of materials with anticancer properties, which is a very promising strategy to treat a variety of malignant lesions with enhanced therapeutic efficacy.
Mavis Forson (17603342), Arisha Ishtiaq (17603357), Adeniyi Oyebade (17802892), Amanda Jalihal (17802895), Adegboyega K. Oyelere (1344141), Nawab Ali (783299), Samantha Macchi (8603340), Robert J. Griffin (247186), Noureen Siraj (1458670), Mujeebat Bashiru (17603345), Amna Khan (735548), Nasrin Hooshmand (1275813)   +11 more
core   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

DNA‐mimic for Specific Surface Functionalization of Zr‐MOFs for Bacterial Targeting

Angewandte Chemie, EarlyView.
We introduce phosphotyrosine‐modified PNA as a superior, single‐step post‐synthesis surface coating for PCN‐222. The DNA mimic allows for controlled post‐functionalization with single‐stranded DNA for the attachment of protein moieties for bacterial targeting. ABSTRACT Nanosized metal–organic frameworks (MOFs) are versatile platforms used in biomedical
Anna Scheeder, Jon Ostolaza‐Paraiso, Andrew G. Baker, Juan F. Blandez, Georgina E. Lindop, Simon M. Fairclough, Ljiljana Fruk, Ioanna Mela, David Fairen‐Jimenez, Clemens F. Kaminski   +9 more
wiley   +2 more sources

Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells

, 2017
Wei Hong,1 Hong Shi,2 Mingxi Qiao,3 Xiang Gao,1 Jie Yang,1 Chunlian Tian,1 Dexian Zhang,1 Shengli Niu,1 Mingchun Liu11Key Laboratory of Zoonosis of Liaoning, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenhe ...
Niu S, Yang J, Zhang D, Liu M, Tian C, Hong W, Gao X, Shi H, Qiao M   +8 more
core  

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source