Results 331 to 340 of about 413,339 (385)
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THE HEPATIC PHARMACOKINETICS OF DOXORUBICIN AND LIPOSOMAL DOXORUBICIN
Drug Metabolism and Disposition, 2004To determine the role of the hepatic sinusoidal endothelium in the hepatic disposition of liposomal doxorubicin, we compared the hepatic pharmacokinetics of doxorubicin hydrochloride and the pegylated, liposomal formulation of doxorubicin (Caelyx). The multiple indicator-dilution technique and electron microscopy were used to study the disposition of ...
Michael Muller +3 more
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Doxorubicin-heparin complex: reduction of cardiotoxicity of doxorubicin
Journal of Cancer Research and Clinical Oncology, 1995We have compared the antitumor activity and cardiotoxicity of free doxorubicin (Dox) and doxorubicin-heparin complex in vivo and in vitro. Dox and Dox-heparin complex equally inhibited the DNA synthesis of leukemic cells and showed a similar anticancer activity against tumor-bearing mice.
Shigeyuki Tachibana +6 more
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Journal of Nanoscience and Nanotechnology, 2014
Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to ...
Kannan, Deepa +2 more
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Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to ...
Kannan, Deepa +2 more
openaire +2 more sources
Pharmacokinetics and metabolism of iodo-doxorubicin and doxorubicin in humans
European Journal of Clinical Pharmacology, 1990The pharmacokinetics of doxorubicin (DOX), iodo-doxorubicin (I-DOX) and their metabolites in plasma has been examined in five patients each receiving 50 mg/m2 of both anthracyclines as a bolus injection. Terminal half-life, mean residence time (MRT), peak plasma concentration Cmax, and area under the curve (AUC) appeared smaller for I-DOX, whereas its ...
K. Burk +4 more
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Human and Experimental Toxicology, 2021
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use. Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via several mechanisms.
S. Owumi, DO Lewu, U. Arunsi, A. Oyelere
semanticscholar +1 more source
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use. Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via several mechanisms.
S. Owumi, DO Lewu, U. Arunsi, A. Oyelere
semanticscholar +1 more source
Determination of Doxorubicin and Doxorubicin-3-ol in Rat Heart [PDF]
, 1986 The discovery of a delayed form of DXR-induced cardiotoxicity raises the question whether the presence of the drug or of metabolites in myocardial cells is necessary for the development of cardiotoxicity. The present investigations deal with a new method for the determination of DXR and of its main metabolite, DXR-3-ol, in cardiac cells. Rat hearts "ex-
Rossini L +3 more
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Journal of Drug Targeting, 1996
Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties of the liposome (size, lipid components and lipid dose) play a major role in determining drug retention ...
P G, Tardi, N L, Boman, P R, Cullis
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Doxorubicin is a potent antineoplastic agent with activity against numerous human cancers. Encapsulation of doxorubicin inside a liposome alters bioavailability, biodistribution and thus its biological activity significantly. The physical properties of the liposome (size, lipid components and lipid dose) play a major role in determining drug retention ...
P G, Tardi, N L, Boman, P R, Cullis
openaire +2 more sources
Annals of Internal Medicine, 1980
Excerpt To the editor: In a recent letter Cosgriff(1) reported onset of ventricular dysrhythmia in a 21-year-old man after administration of doxorubicin and noted the association of doxorubicin, dy...
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Excerpt To the editor: In a recent letter Cosgriff(1) reported onset of ventricular dysrhythmia in a 21-year-old man after administration of doxorubicin and noted the association of doxorubicin, dy...
openaire +3 more sources