Results 351 to 360 of about 413,339 (385)

Hepatotoxicity of mitoxantrone and doxorubicin

Toxicology, 1990
Doxorubicin and mitoxantrone were given to mice in a single dose of 15 mg/kg body wt (i.p.) and lipid peroxidation assays were carried out 3, 4 and 5 days after injection. Four days after injection, mitoxantrone induced an increase of 155% in liver spontaneous chemiluminescence and increases of 73% and 52% in malonaldehyde levels and hydroperoxide ...
Silvia Lores Arnaiz, Susana Llesuy
openaire   +3 more sources

Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98.

Journal of Clinical Oncology, 2013
PURPOSE Previous preclinical and clinical data suggest that the immune system influences prognosis and response to chemotherapy (CT); however, clinical relevance has yet to be established in breast cancer (BC).
S. Loi, N. Sirtaine, F. Piette, R. Salgado, G. Viale, F. Van Eenoo, G. Rouas, P. Francis, J. Crown, E. Hitre, E. de Azambuja, E. Quinaux, A. Di Leo, S. Michiels, M. Piccart, C. Sotiriou   +15 more
semanticscholar   +1 more source

Doxorubicin-Induced Cardiomyopathy

New England Journal of Medicine, 1998
Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held promise as a powerful drug in the fight against cancer. The tumors most commonly responding to doxorubicin when it is given as a single agent or in combination with other antitumor agents include breast and esophageal carcinomas; osteosarcoma, Kaposi's sarcoma ...
Natasha Iliskovic, Pawan K. Singal
openaire   +3 more sources

Doxorubicin in Disseminated

JAMA: The Journal of the American Medical Association, 1972
Doxorubicin (adriamycin) is a new cytotoxic antibiotic with antitumor activity in a variety of neoplasms in man. Thirteen patients with pulmonary metastases from osteogenic sarcoma were given adriamycin at a dose ranging from 17.5 to 35 mg/sq m of body surface area daily for three or four days, repeated at monthly intervals.
Engracio P. Cortes, Jaw J. Wang, James F. Holland, Lucius F. Sinks   +3 more
openaire   +2 more sources

Mediastinal extravasation of doxorubicin

Clinical and Translational Oncology, 2008
A 48-year-old woman with a diagnosis of breast carcinoma was treated with adjuvant chemotherapy through a central venous catheter with subcutaneous reservoir (Port-A-Cath). While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent ...
Luis López Gómez, Cristina Pangua Méndez, María Blanca Martínez-Barbeito, Adolfo Blanco Jarava, Jesús Andrade Santiago, Ignacio Chacón López-Muñiz, Teresa Quintanar Verdúguez   +6 more
openaire   +3 more sources

Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches

Cardiovascular Toxicology, 2022
Mohammad Sheibani, Yaser Azizi, M. Shayan, S. Nezamoleslami, Faeze Eslami, M. Farjoo, A. Dehpour   +6 more
semanticscholar   +1 more source

Risk factors for doxorubicin-induced congestive heart failure.

Annals of Internal Medicine, 1979
Potential risk factors responsible for development of doxorubicin-induced congestive heart failure were examined through retrospective analysis of 4018 patient records.
D. D. Hoff, M. Layard, Peter Basa, H. Davis, Ann L. Von Hoff, M. Rozencweig, F. Muggia   +6 more
semanticscholar   +1 more source

A comprehensive review on time-tested anticancer drug doxorubicin.

Life Science, 2021
Sruthi Sritharan, Nageswaran Sivalingam
semanticscholar   +1 more source

Doxorubicin and multidrug resistance

Current Opinion in Oncology, 1993
The circumvention of P-glycoprotein function by pharmacologic agents is a major focus of clinical trials aimed at increasing the cytotoxicity of multidrug resistance-associated drugs, including doxorubicin. The success of this approach will likely depend on the clinical significance of P-glycoprotein expression, which has not yet been elucidated for ...
Gary D. Kruh, Lori J. Goldstein
openaire   +2 more sources

Acute Doxorubicin Overdoses

Annals of Internal Medicine, 1991
Excerpt To the Editors:Twelve accidental acute doxorubicin overdoses (range, 3 to 10 times intended dose) have been reported to Adria Laboratories (Columbus, Ohio) since 1977.
openaire   +3 more sources