Results 121 to 130 of about 150,359 (342)

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts

, 2019
Mazen Saeed,1 Mehmet Zuhuri Arun,2 Mehmet Guzeloglu,3 Ceylan Onursal,1 Goksel Gokce,2 Ceren Gonen Korkmaz,2 Buket Reel21Ege University, Faculty of Pharmacy, Department of Pharmacology, 35100 Bornova, Izmir, Turkey; 2Ege University, Faculty of Pharmacy ...
Reel B, Arun MZ, Onursal C, Saeed M, Guzeloglu M, Gokce G, Korkmaz CG   +6 more
core  

Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models

Arthritis &Rheumatology, EarlyView.
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis, Sabrina Narvesen, Deeva Robles Kuriplach, Karen Huang, Teja Sundar, Elizabeth Bagley, Joanna Parkes, Xinyu Jia, Nandhana Sudhan, Alfredo Guzman, Kanneboyina Nagaraju, Melissa Morales   +11 more
wiley   +1 more source

Mefloquine and doxycycline malaria prophylaxis in the Australian soldiers in East Timor

, 2005
Objectives: To describe the tolerability of mefloquine in Australian soldiers for malaria prophylaxis, including a comparison with doxycycline. Design: Open-label, prospective study and cross-sectional questionnaire and interview.
Edstein, Michael D., Kitchener, Scott J., Nasveld, Peter E., Gregory, Robin M.   +3 more
core  

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Long-term use of doxycycline can improve chronic asthma and possibly remodeling: the result of a pilot observation

, 2012
Parthasarathi Bhattacharyya, Rantu Paul, Partha Bhattacharjee, Arko Ghosh, Ratna Dey, Malabika Ghosh, Madan SharmaInstitute of Pulmocare and Research, CB 16, Salt Lake, Sector 1, Kolkata-700064, IndiaAbstract: Progressive loss of lung function and ...
Ghosh A, Bhattacharjee P, Ghosh M, Dey R, Bhattacharyya P, Paul R, Sharma M   +6 more
core  

Drug modifications:graphene oxide-chitosan loading enhanced anti-amoebic effects of pentamidine and doxycycline [PDF]

Acanthamoeba castellanii is the causative pathogen of a severe eye infection, known as Acanthamoeba keratitis and a life-threatening brain infection, named granulomatous amoebic encephalitis.
Alawfi, Bader S., Alawfi, B. S, Daalah, M, Anwar, A, Gul, Jasra, Jabri, Tooba, Ahmed, Usman, Ying, T. Y, Ying, Tan Yee, Ahmed, U, Tong, Y. J, Shah, M. R, Gul, J, Tong, Yeo Jia, Siddiqui, Ruqaiyyah; id_orcid, Siddiqui, R, Shah, Muhammad Raza, Khan, N., Khan, Naveed Ahmed, Daalah, Meshal, Jabri, T, Anwar, Ayaz   +21 more
core   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Degradation of doxycycline in aged pig manure

, 2011
Two types of studies were carried out to characterise the degradation rate of doxycycline in manure. In the laboratory experiment, pig manure containing doxycycline was stored in biochemical oxygen demand (BOD) bottles in a thermoregulated room at a ...
István Szatmári, Péter Laczay, Zsuzsa Borbély   +2 more
core   +2 more sources

Chlorogenic acid attenuates tet (X)-mediated doxycycline resistance of Riemerella anatipestifer

Frontiers in Veterinary Science
IntroductionThe increasing resistance of R. anatipestifer has posed a significant threat to the poultry industry in recent years. The tet gene is the primary determinant of tetracycline resistance in numerous bacteria, and the enzyme modification gene ...
Yuwen Han, Min Li, Dehai Su, Shiyu Xiong, Youshu Feng, Qin Deng, Huanzhong Ding   +6 more
doaj   +1 more source