Results 101 to 110 of about 150,359 (342)

Efek Doxycycline dosis rendah terhadap jumlah serat kolagen tikus wistar yang diinduksi agregatebacter actinomycetemcomitans. [PDF]

, 2011
Background. Periodontitis is characterized by periodontal tissue destruction such as destruction of collagen fibers, periodotal ligament and alveolar bone that cause tooth mobility.
Erni Maduratna, Setiawati
core  

Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model

Inflammation, 2020
Acute lung injury is an inflammatory condition developed after severe sepsis in response to excessive secretion of pro-inflammatory cytokines. Doxycycline is widely reported to possess immunomodulatory activity through inhibition of various inflammatory ...
Anasuya Patel, H. Khande, H. Periasamy, S. Mokale   +3 more
semanticscholar   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Rapid generation of secondary fibroblasts through teratoma formation

BioTechniques, 2015
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci.
Sang Mi Cho, Jung Sun Park, Byungkuk Min, Sujin Kwon, Yong-Kook Kang   +4 more
doaj   +1 more source

Evaluation of the doxycycline release from AH26 sealer-doxycycline combination: An ex vivo study

, 2011
INTRODUCTION: The purpose of this ex vivo study was to determine the releasing characteristics and doxycycline dentinal diffusion of AH26 sealer-doxycycline combination from apical 3mm of tooth root and apical foramen.
Noushin Shokouhinejad, Yazdi, Kazem Ashofteh, Moazeni, Esmaeil, Kazem Ashofteh Yazdi, Shokouhinejad, Noushin, Mirzayi Rad, Sina, Sina Mirzayi Rad, Esmaeil Moazeni   +7 more
core   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Early syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin

Journal of Infection in Developing Countries, 2014
Introduction: Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with ...
Jun Li, He-Yi Zheng
doaj   +1 more source

A Combination of Ivermectin and Doxycycline Possibly Blocks the Viral Entry and Modulate the Innate Immune Response in COVID-19 Patients

, 2020
The current outbreak of the corona virus disease 2019 (COVID-19), has affected almost entire world and become pandemic now. Currently, there is neither any FDA approved drugs nor any vaccines available to control it.
Dharmendra Kumar, Maurya
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source