Results 81 to 90 of about 150,359 (342)

The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats

Journal of Ophthalmology, 2019
Purpose. To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods. Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the ...
Qiong Yi, Wen-jin Zou
doaj   +1 more source

Suppression of MMP-9 by doxycycline in brain arteriovenous malformations

BMC Neurology, 2005
Background The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs).
Li Jenny F, Matsumoto Melissa M, Hashimoto Tomoki, Lawton Michael T, Young William L   +4 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Impact of the antibiotic doxycycline on the D. magna reproduction, associated microbiome and antibiotic resistance genes in treated wastewater conditions

, 2023
Wastewater Treatment Plant (WWTP) effluents are important sources of antibiotics, antibiotic resistance genes (ARGs) and resistant bacteria that threaten aquatic biota and human heath. Antibiotic effects on host-associated microbiomes, spread of ARGs and
Casado, Marta, Barata, Carlos, Maria Vila-Costa, Maria Paula Carrillo, Pastor-López, Edward J., Vila-Costa, Maria, Marta Casado, Carlos Barata, Carrillo, Maria Paula, Marina Sevilla, Pastor López, Edward, Piña, Benjamín, Edward Pastor López, Matamoros, Víctor, Sevilla, Marina, Victor Matamoros, Barata Martí, Carlos, Benjamin Piña   +17 more
core   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant Pseudomonas aeruginosa Tunisian Clinical Isolates

Antibiotics, 2020
The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are ...
Azza Troudi, Meha Fethi, Mohamed Selim El Asli, Jean Michel Bolla, Naouel Klibi, Jean Michel Brunel   +5 more
doaj   +1 more source

Doxycycline in clinical Medicine

, 2010
Doxycycline is one of the most commonly used antibiotics in clinical medicine. Its broad spectrum of activity along with tolerable adverse effects makes it more palatable and compliant to patients.
J. Sagar
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial

The Lancet, 2017
Summary Background Bullous pemphigoid is a blistering skin disorder with increased mortality. We tested whether a strategy of starting treatment with doxycycline gives acceptable short-term blister control while conferring long-term safety advantages ...
H. Williams, F. Wojnarowska, G. Kirtschig, J. Mason, T. Godec, E. Schmidt, J. Chalmers, M. Childs, S. Walton, K. Harman, A. Chapman, D. Whitham, A. Nunn, J V A C H S E A R R F K R J R R C P J N R K J A M N Adams Akhras Anstey Barnard Bell Blackford Bröcker, J. Adams, V. Akhras, A. Anstey, C. Barnard, H. Bell, S. Blackford, E. Bröcker, A. Carmichael, R. Coelho, F. Craig, K. Davies, R. Ellis, J. English, R. Gläser, R. Groves, C. Günthert, P. Hampton, N. Hepburn, R. Hügel, K. Hussain, J. Ingram, A. Layton, N. Levell, V. Lewis, H. Malhomme, A. Omerod, G. Patel, R. Rallan, J. Ravenscroft, H. Santander, K. Steinbrink, M. Sticherling, C. Thomas, M. Vatve, N. van Beek, V. Venning, E. Veysey, R. Wachsmuth, S. Wahie, B. Walker, M. Walsh, J. Wee, M. Westmoreland, G. Wong, A. Ferguson, I. Verpetinske, E. Duarte-Williamson, F. Antony, Chris W Bower, D. Gawkrodger, K. Taghipour, M. Dunnill, A. Waters, W. Bottomley, A. Wright, J. Sterling, A. Azam, S. Gibbs, T. Luger, I. Salvary, C. Lovell, A. Ilchyshyn, K. Gibbon, M. Nik, R. Charles-Holmes, A. L. Lavery   +79 more
semanticscholar   +1 more source

Tissue Distribution of Doxycycline in Animal Models of Tuberculosis

Antimicrobial Agents and Chemotherapy, 2020
Doxycycline, an FDA-approved tetracycline, is used in tuberculosis in vivo models for the temporal control of mycobacterial gene expression. In these models, animals are infected with recombinant Mycobacterium tuberculosis carrying genes of interest ...
M. Gengenbacher, M. Zimmerman, Jansy P. Sarathy, Firat Kaya, Han Wang, Marizel Mina, C. Carter, Md Amir Hossen, H. Su, C. Trujillo, S. Ehrt, D. Schnappinger, V. Dartois   +12 more
semanticscholar   +1 more source