Results 61 to 70 of about 124,618 (258)

Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax [PDF]

International audienceABSTRACT Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline.
Christensen, Peter, Cinzah, Rosy, Kyle, Dennis, Cook, Gregory M., Yen Chua, Adeline Chiew, Russell, Bruce, Chua, Adeline Chiew Yen, Rénia, Laurent, Aung, Htin Lin, Kaneko, Osamu, Matheson, Jessica, Snounou, Georges, Cook, Gregory, Kyle, Dennis E., Suwanarusk, Rossarin, https://orcid.org/, Bifani, Pablo   +16 more
core   +2 more sources

Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells [PDF]

The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction is a key-characteristic of clinical AAA disease.
Wanga, S., Lindeman, J.H.N., Vries, C.J.M. de, Waard, V. de, Yap, C., Os, B.W. van, Wuest, R.C.I., Keijzer, S., Pijls, M.M.E., Zanten, E. van, Koolbergen, D.R., Driessen, A.H.G., Balm, R., Yeung, K.K., Houtkooper, R.H.   +14 more
core   +2 more sources

Azithromycin and doxycycline intravenous and oral administrations before and after prescriber-facing alert for intravenous fluid conservation

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: Intravenous (IV) to oral (PO) antimicrobial stewardship initiatives can be implemented by various healthcare providers in conjunction with clinical decision support tools. Our study evaluated the impact of a prescriber-facing IV to PO alert on
Jennifer Dela-Pena, Jill Wesolowski, Gretchen Sacha, Andrea M. Pallotta   +3 more
doaj   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Effect of doxycycline on atherosclerosis: From bench to bedside [PDF]

, 2011
Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in ...
Rodriguez Granillo, Agustina, Milei, Jose, Rodriguez Granillo, Gaston Alfredo   +2 more
core  

Mefloquine and doxycycline malaria prophylaxis in the Australian soldiers in East Timor

, 2005
Objectives: To describe the tolerability of mefloquine in Australian soldiers for malaria prophylaxis, including a comparison with doxycycline. Design: Open-label, prospective study and cross-sectional questionnaire and interview.
Edstein, Michael D., Kitchener, Scott J., Nasveld, Peter E., Gregory, Robin M.   +3 more
core   +1 more source

Rapid generation of secondary fibroblasts through teratoma formation

BioTechniques, 2015
The use of secondary or reprogrammable cells in the production of induced pluripotent stem cells (iPSCs) circumvents random infection by various viral particles and random, uncontrollable integrations of the viral genomes into different genomic loci.
Sang Mi Cho, Jung Sun Park, Byungkuk Min, Sujin Kwon, Yong-Kook Kang   +4 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats

Animals
Doxycycline is a second-generation tetracycline, marketed in different species for treating infections caused by susceptible bacteria. Little information is available on the pharmacokinetics of doxycycline in lactating goats.
José Martínez, Elisa Escudero, Elena Badillo, María Teresa Yuste, Juan Sebastián Galecio, Pedro Marin   +5 more
doaj   +1 more source