Results 61 to 70 of about 150,359 (342)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria

Cancer Cell International, 2010
Background Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug ...
Sagar Jayesh, Sales Kevin, Taanman Jan-Willem, Dijk Sas, Winslet Marc   +4 more
doaj   +1 more source

Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii.

Aquatic Toxicology, 2018
Microplastics and pharmaceuticals are considered ubiquitous and emergent pollutants of high concern but the knowledge on their effects on primary producers is still limited, especially those caused by mixtures.
J. C. Prata, Beatriz R B O Lavorante, M. D. C. B S M Montenegro, L. Guilhermino   +3 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Effect of Doxycycline on Glomerulosclerosis in 5/6 Renal Ablation Nephropathy

, 2020
Objectives:The beneficial effect of matrix metalloproteinases (MMP) inhibitors in renal diseases has been reported. Their effect in segmental sclerosis is unknown.
Ali Çelik, Kahraman, Devrim, Sulen Sarıoğlu, Çelik, Ali, Devrim Kahraman, Funda Sağlam, Zahide Çavdar, Sarıoğlu, Sülen, Sağlam, Funda, Kolatan, Hatice Efsun, Osman Yılmaz, Efsun Kolatan, Yılmaz, Osman, Çavdar, Zahide   +13 more
core   +1 more source

Doxycycline Prophylaxis for Bacterial Sexually Transmitted Infections

Clinical Infectious Diseases, 2019
Bacterial sexually transmitted infections (STIs) have been increasing over the past 2 decades in gay, bisexual, and other men who have sex with men. With the widespread use of early human immunodeficiency virus (HIV) treatment, which virtually eliminates
Juliana S Grant, C. Stafylis, C. Celum, T. Grennan, B. Haire, J. Kaldor, A. Luetkemeyer, J. Saunders, J. Molina, J. Klausner   +9 more
semanticscholar   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Effect of doxycycline on atherosclerosis: From bench to bedside [PDF]

, 2011
Matrix metalloproteinases (MMPs) have a pivotal role in the natural history of atherosclerosis and its cardiovascular consequences. Non-selective MMP inhibition with doxycycline appears as a potential strategy to reduce the residual risk observed in ...
Rodriguez Granillo, Agustina, Milei, Jose, Rodriguez Granillo, Gaston Alfredo   +2 more
core  

In vitro and In vivo Anti-Filarial Effect of Tetracycline/ Doxycycline

, 2017
Tetracycline is an established antibiotic and is targets to Wolbachia endosymbiont present within the filarial worms. Antibiotic treatment of filarial nematodes results in sterility and inhibits larval development and adult worm viability; this is due to
AK Gupta, Salauddin Qureshi, Vanadana Dixit, Subuhi Khan, GBKS Prasad   +4 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source