Results 71 to 80 of about 150,359 (342)

Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines

Tumor Biology, 2017
Gallbladder carcinoma is the most common and aggressive malignancy of the biliary tree and highly expresses CD147, which is closely related to disease prognosis in a variety of human cancers.
Shihang Wang, Chao Liu, Xinjiang Liu, Yanxin He, Dongfang Shen, Qiankun Luo, Yuxi Dong, Haifeng Dong, Zhigang Pang   +8 more
doaj   +1 more source

Minireview: Prospect of Doxycycline in Systemic Lupus Erythematosus Treatment

Journal of Tropical Pharmacy and Chemistry, 2019
Doxycycline has non-antibiotic effects which are necessary for lupus treatment, such as immunosuppressive, anti-inflammatory, and anti-depressive effects.
Niken Indriyanti, Joewono Soeroso
doaj   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

The Comparison of Doxycycline Residue in the Meat of Broiler Chickens Administered in Feed and Water

Media Peternakan, 2011
The purpose of this research was to investigate the effect of doxycycline (a tetracycline derivative) administered at disease-prevention dose given daily in the feed and drinking water on the residue level in the broiler-chicken meat.
A. D. Wijayanti, Wihandoyo, A. W. Rosetyadewi   +2 more
doaj  

PROPHYLACTIC ADMINISTRATION OF DOXYCYCLINE REDUCES CENTRAL VENOUS CATHETER INFECTIONS IN PATIENTS UNDERGOING HEMATOPOIETIC CELL TRANSPLANTATION

Mediterranean Journal of Hematology and Infectious Diseases, 2013
Hematopoietic stem cells are usually transfused through a central venous catheter (CVC), which also facilitates administration of medications and intravenous fluids.
Mohamed Kharfan-Dabaja, Mohamed Baydoun, Zaher Otrock, Samar Okaily, Rita Nehme, Racha Abu-Chahine, Ali Hamdan, Samar Noureddine, Souha Kanj, Zeina Kanafani, Ali Bazarbachi   +10 more
doaj   +1 more source

Comprehensive Adsorption Studies of Doxycycline and Ciprofloxacin Antibiotics by Biochars Prepared at Different Temperatures

Frontiers in Chemistry, 2018
This paper comparatively investigated the removal efficiency and mechanisms of rice straw biochars prepared under three pyrolytic temperatures for two kinds of tetracycline and quinolone antibiotics (doxycycline and ciprofloxacin).
Zhi-wei Zeng, Xiao Tan, Yun-guo Liu, Sirong Tian, Guang-ming Zeng, Lu Jiang, Shao-Bo Liu, Jiang Li, Ni Liu, Zhibing Yin   +9 more
semanticscholar   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Supramolecular Arrangement of Doxycycline with Sulfobutylether-β-Cyclodextrin: Impact on Nanostructuration with Chitosan, Drug Degradation and Antimicrobial Potency

Pharmaceutics, 2023
Doxycycline (DX) is a well-established and broad-spectrum antimicrobial drug. However, DX has drawbacks, such as physicochemical instability in aqueous media and bacterial resistance.
Renata Carvalho Feitosa, Juliana Souza Ribeiro Costa, Marcelo van Vliet Lima, Elina Sawa Akioka Ishikawa, Karina Cogo Müller, Fernando Bonin Okasaki, Edvaldo Sabadini, Claudia Garnero, Marcela Raquel Longhi, Vladimir Lavayen, Arnóbio Antônio da Silva-Júnior, Laura Oliveira-Nascimento   +11 more
doaj   +1 more source

Doxycycline for osteoarthritis of the knee or hip [PDF]

, 2012
Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that doxycycline might act as a disease-modifying agent for the treatment of osteoarthritis, with the potential to slow cartilage ...
Da Costa, Bruno, Nüesch, Eveline, Reichenbach, Stephan, Jüni, Peter, Rutjes, Anne W S   +4 more
core   +1 more source

Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan, Anna K. McClain, Andrea Trementozzi, Sogu Sohn, Lingxia Qiao, Chi Zhao, Padmini Rangamani, Jeanne C. Stachowiak, Janet Zoldan   +8 more
wiley   +1 more source