Results 71 to 80 of about 124,618 (258)
Journal of Infection in Developing Countries, 2014 Introduction: Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with ...
Jun Li, He-Yi Zheng
doaj +1 more source
Advanced Science, EarlyView.Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin +7 more
wiley +1 more source
EBioMedicineSummary: Background: Clinical trials showed a single oral dose of doxycycline taken after sex protects against STIs among men who have sex with men (MSM) but not women. Pharmacokinetic data at vaginal, rectal and penile sites of STI exposure are lacking.
Richard E. Haaland +8 more
doaj +1 more source
Advanced Science, EarlyView.DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang +8 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang +14 more
wiley +1 more source
Advanced Science, EarlyView.A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon +12 more
wiley +1 more source
Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice
Advanced Science, EarlyView.CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu +8 more
wiley +1 more source
Inhibition of doxycycline on epithelial ovarian cancer cells invasion.
, 2014 Cells were cultured in transwell with indicated doxycycline for 36/DDP cells by 4 and 2 folds respectively. a: 100 µl serum-free cell suspension (after cells attached) with doxycycline-treated (10 µg/ml) in coated insert filters; 500 µl serum-free RPMI ...
Li-hua Yu (530861) +3 more
core +1 more source
SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition
Advanced Science, EarlyView.The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang +9 more
wiley +1 more source