Results 51 to 60 of about 25,207 (238)

Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines

Tumor Biology, 2017
Gallbladder carcinoma is the most common and aggressive malignancy of the biliary tree and highly expresses CD147, which is closely related to disease prognosis in a variety of human cancers.
Shihang Wang, Chao Liu, Xinjiang Liu, Yanxin He, Dongfang Shen, Qiankun Luo, Yuxi Dong, Haifeng Dong, Zhigang Pang   +8 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

The Comparison of Doxycycline Residue in the Meat of Broiler Chickens Administered in Feed and Water

Media Peternakan, 2011
The purpose of this research was to investigate the effect of doxycycline (a tetracycline derivative) administered at disease-prevention dose given daily in the feed and drinking water on the residue level in the broiler-chicken meat.
A. D. Wijayanti, Wihandoyo, A. W. Rosetyadewi   +2 more
doaj  

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Minireview: Prospect of Doxycycline in Systemic Lupus Erythematosus Treatment

Journal of Tropical Pharmacy and Chemistry, 2019
Doxycycline has non-antibiotic effects which are necessary for lupus treatment, such as immunosuppressive, anti-inflammatory, and anti-depressive effects.
Niken Indriyanti, Joewono Soeroso
doaj   +1 more source

Supramolecular Arrangement of Doxycycline with Sulfobutylether-β-Cyclodextrin: Impact on Nanostructuration with Chitosan, Drug Degradation and Antimicrobial Potency

Pharmaceutics, 2023
Doxycycline (DX) is a well-established and broad-spectrum antimicrobial drug. However, DX has drawbacks, such as physicochemical instability in aqueous media and bacterial resistance.
Renata Carvalho Feitosa, Juliana Souza Ribeiro Costa, Marcelo van Vliet Lima, Elina Sawa Akioka Ishikawa, Karina Cogo Müller, Fernando Bonin Okasaki, Edvaldo Sabadini, Claudia Garnero, Marcela Raquel Longhi, Vladimir Lavayen, Arnóbio Antônio da Silva-Júnior, Laura Oliveira-Nascimento   +11 more
doaj   +1 more source

In vitro and In vivo Anti-Filarial Effect of Tetracycline/ Doxycycline

, 2017
Tetracycline is an established antibiotic and is targets to Wolbachia endosymbiont present within the filarial worms. Antibiotic treatment of filarial nematodes results in sterility and inhibits larval development and adult worm viability; this is due to
AK Gupta, Salauddin Qureshi, Vanadana Dixit, Subuhi Khan, GBKS Prasad   +4 more
core   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source