Results 51 to 60 of about 150,359 (342)

Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease

Therapeutic Advances in Respiratory Disease, 2020
Infection with novel SARS-CoV-2 carries significant morbidity and mortality in patients with pulmonary compromise, such as lung cancer, autoimmune disease, and pneumonia.
P. Yates, S. Newman, L. Oshry, R. Glassman, A. Leone, E. Reichel   +5 more
semanticscholar   +1 more source

Safety and efficacy of doxycycline

, 2009
Doxycycline has remained one of the most commonly used and inexpensive of the broad-spectrum antibiotic drugs currently in use. It has a variety of applications to common respiratory and genitourinary tract infections, but also amongst atypical ...
Peter A. Leggat, Leggat, Peter A.
core   +1 more source

A Randomized Controlled Trial of Ceftriaxone and Doxycycline, with or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease.

Clinical Infectious Diseases, 2020
BACKGROUND Anaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID). The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity.
H. Wiesenfeld, L. Meyn, T. Darville, I. Macio, S. Hillier   +4 more
semanticscholar   +1 more source

Doxycycline-induced fixed drug eruption: A case series highlighting a dermatological concern in antimicrobial stewardship

International Journal of Infectious Diseases
Objectives: To describe a series of doxycycline-induced fixed drug eruptions (FDE) observed in sexual health clinics, in a context of increasing doxycycline use for sexually transmitted infection (STI) management and prophylaxis in France.
Clément Brun, Marie Danset, Romain Salle, Victor Bourdenet, Louise Jaulent, Florence Hacard, Marine Fargeas, Brigitte Milpied, Elisa Goujon, Valérie Beaulieu, Timothy Capeliez, Sébastien Fouéré, Matthieu Godinot, Marie Tauber   +13 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The effect of laser irradiation and doxycycline application on the production of matrix metalloproteinase-8 and collagen I from cultured human periodontal ligament cells

Dental Research Journal, 2020
Background: Periodontal ligament fibroblasts (PDLF) play a key role in periodontal wound healing and tooth-supporting structures. Various approaches have been tried to enhance the fibroblastic activity such as laser irradiation or doxycycline application.
Alireza Dehdashtizadeh, Nasim Esnaashari, Shirin Zahra Farhad, Fatemeh Ejeian, Shaharam Amini   +4 more
doaj   +1 more source

Microwave-Assisted, One-Pot Synthesis of Doxycycline under Heterogeneous Catalysis in Water

Antibiotics, 2021
The selective synthesis of active pharmaceutical molecules is a challenging issue, particularly when attempting to make the reactions even more sustainable.
Fabio Bucciol, Elia Maffeis, Emanuela Calcio Gaudino, László Jicsinszky, Silvia Tagliapietra, Alessandro Barge, Cristina Prandi, Giancarlo Cravotto   +7 more
doaj   +1 more source

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

bioRxiv, 2020
Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn).
Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, F. González-Lizárraga, Annekatrin König, Diana F. Lázaro, A. Lannuzel, S. Haik, E. Del Bel, R. Chehín, R. Raisman‐Vozari, P. Michel, N. Bizat, T. Outeiro   +13 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study

Journal of Pharmacy and Bioallied Sciences
Background: Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset.
Dhawal Rajendra Mody, Vrushali Lathiya, Abhay P. Kolte, Vaishnavi Biradar, Vaishnavi Langde   +4 more
doaj   +1 more source