Results 51 to 60 of about 124,618 (258)
A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans
Advanced Science, EarlyView.This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao +19 more
wiley +1 more source
IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis
Advanced Science, EarlyView.The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui +12 more
wiley +1 more source
Doxycycline in clinical Medicine
, 2010 Doxycycline is one of the most commonly used antibiotics in clinical medicine. Its broad spectrum of activity along with tolerable adverse effects makes it more palatable and compliant to patients.
J. Sagar
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Efek Doxycycline dosis rendah terhadap jumlah serat kolagen tikus wistar yang diinduksi agregatebacter actinomycetemcomitans. [PDF]
, 2011 Background. Periodontitis is characterized by periodontal tissue destruction such as destruction of collagen fibers, periodotal ligament and alveolar bone that cause tooth mobility.
Erni Maduratna, Setiawati
core +1 more source
Advanced Science, EarlyView.EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li +9 more
wiley +1 more source
, 1999 A prospective, open, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of the conventional four-drug combination (chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline) with that of doxycycline alone in ...
Smith, MD +5 more
core +1 more source
The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats
Journal of Ophthalmology, 2019 Purpose. To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods. Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the ...
Qiong Yi, Wen-jin Zou
doaj +1 more source
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Effect of Systemic Doxycycline on Scaling and Root Planing in Chronic Periodontitis
Journal of Integrated Health Sciences, 2019 Background: Periodontitis is a multifactorial chronic inflammatory disease. It occurs due to inflammation and tooth-supporting tissues destruction by subgingival microbiota.
Dhwani Vyas +2 more
doaj +1 more source
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source