Results 41 to 50 of about 124,618 (258)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines

Tumor Biology, 2017
Gallbladder carcinoma is the most common and aggressive malignancy of the biliary tree and highly expresses CD147, which is closely related to disease prognosis in a variety of human cancers.
Shihang Wang, Chao Liu, Xinjiang Liu, Yanxin He, Dongfang Shen, Qiankun Luo, Yuxi Dong, Haifeng Dong, Zhigang Pang   +8 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

The Comparison of Doxycycline Residue in the Meat of Broiler Chickens Administered in Feed and Water

Media Peternakan, 2011
The purpose of this research was to investigate the effect of doxycycline (a tetracycline derivative) administered at disease-prevention dose given daily in the feed and drinking water on the residue level in the broiler-chicken meat.
A. D. Wijayanti, Wihandoyo, A. W. Rosetyadewi   +2 more
doaj  

Oral efficacy of controlled-release doxycycline against Ichthyophthirius multifiliis infestation in salmonids

Veterinární Medicína
Ichthyophthiriosis, caused by Ichthyophthirius multifiliis, is a major threat in salmonid aquaculture. This study evaluated the efficacy of orally administered standard doxycycline and controlled-release doxycycline formulations in experimentally ...
Z Mikulkova, K Matejickova, J Motlova, P Ginterova, M Jerabek, L Pojezdal   +5 more
doaj   +1 more source

Supramolecular Arrangement of Doxycycline with Sulfobutylether-β-Cyclodextrin: Impact on Nanostructuration with Chitosan, Drug Degradation and Antimicrobial Potency

Pharmaceutics, 2023
Doxycycline (DX) is a well-established and broad-spectrum antimicrobial drug. However, DX has drawbacks, such as physicochemical instability in aqueous media and bacterial resistance.
Renata Carvalho Feitosa, Juliana Souza Ribeiro Costa, Marcelo van Vliet Lima, Elina Sawa Akioka Ishikawa, Karina Cogo Müller, Fernando Bonin Okasaki, Edvaldo Sabadini, Claudia Garnero, Marcela Raquel Longhi, Vladimir Lavayen, Arnóbio Antônio da Silva-Júnior, Laura Oliveira-Nascimento   +11 more
doaj   +1 more source

Transparent Single‐Dye NIR Photonic Platform for Multimodal Optical Authentication

Advanced Optical Materials, EarlyView.
A single‐component DHP‐SQ dye integrates visible transparency, near‐infrared (NIR) fluorescence, and photothermal functionality into one molecular platform. NIR‐selective visualization transforms visually imperceptible printed patterns into readily authenticated information, while screen‐printing compatibility enables well‐defined patterning on diverse
Su Jeong Choi, Seung Hyeon Kim, Dayoung Shin, Yeongnam Heo, Minseo Kim, Ji Hyeon Lee, Ji‐Eun Jeong, Young‐Jae Jin, Jin Chul Kim, Hyoung Eun Bae, Young Hoon Son, Sung Jin Park, Sang Hwan Nam, Young Il Park, Hyocheol Jung   +14 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Relapses and therapeutic failures with the combined doxycycline-gentamicin regimen and doxycycline-rifampicin regimen reported by treatment duration.

, 2012
Relapses and therapeutic failures with the combined doxycycline-gentamicin regimen and doxycycline-rifampicin regimen reported by treatment duration.
Javier Solera (180241), Julián Solís García del Pozo (180235)   +1 more
core   +1 more source

Efficiency of a Tetracycline-Adjuvant Combination Against Multidrug Resistant Pseudomonas aeruginosa Tunisian Clinical Isolates

Antibiotics, 2020
The growing number of multidrug resistant strains in Tunisia has become a serious health concern contributing to high rate of mortality and morbidity. Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are ...
Azza Troudi, Meha Fethi, Mohamed Selim El Asli, Jean Michel Bolla, Naouel Klibi, Jean Michel Brunel   +5 more
doaj   +1 more source