Results 41 to 50 of about 150,359 (342)

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation

Journal of International Medical Research, 2021
Objectives The anti-cancer activity of doxycycline has been reported in many cancers but not renal cell carcinoma (RCC). This study aimed to determine the efficacy of doxycycline alone and in combination with paclitaxel and analyze the underlying ...
Bo Wang, Jinsong Ao, Xiaoyan Li, Weimin Yu, Dan Yu, Chengjun Qiu   +5 more
doaj   +1 more source

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

International Journal of Molecular Sciences, 2021
Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results in ...
R. C. Wüst, B. Coolen, N. Held, Mariah R R Daal, Vida Alizadeh Tazehkandi, Luciënne Baks-te Bulte, M. Wiersma, D. Kuster, B. Brundel, M. van Weeghel, G. Strijkers, R. Houtkooper   +11 more
semanticscholar   +1 more source

Dengue and Scrub Typhus Coinfection: A Diagnostic Dilemma

Oman Medical Journal, 2023
Due to overlapping clinical features, scrub typhus infection may be missed in presence of dengue. Concurrent infection with those two pathogens is rare and creates a diagnostic dilemma. We present a case of a 65-year-old male who was admitted with a high-
Atanu Chandra, Arkapravo Hati, Aritra Kumar Ray, Uddalak Chakraborty, Partha Sarathi Karmakar, Sugata Dasgupta   +5 more
doaj   +1 more source

Doxycycline-induced bioluminescence in the mammary gland of the MTB/Cat^TMILA bigenic.

, 2017
(A) Overlay of full-body bioluminescence and x-ray images of monogenic control (G6719 (ear tag#)) and MTB/CatTMILA bigenic (G6718 (ear tag#)) mice following 0, 24, and 48 hours of doxycycline intake.
Maria M. Szwarc (476339), Lan Hai (3808492), John P. Lydon (476343), Ramakrishna Kommagani (476338), David M. Lonard (554019), Mary C. Peavey (2585938)   +5 more
core   +1 more source

Doxycycline for osteoarthritis of the knee or hip [PDF]

, 2008
BACKGROUND: Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that doxycycline might act as a disease-modifying agent for the treatment of osteoarthritis, with the potential to slow ...
Trelle, Sven, Peter Jüni, Eveline Nüesch, Nüesch, Eveline, Reichenbach, Stephan, Jüni, Peter, Anne WS Rutjes, Rutjes, Anne Ws, Sven Trelle, Stephan Reichenbach   +9 more
core   +1 more source

Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy.

, 2010
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Luft, F.C., Mueller, D.N., Lydia Hering, Morton, J., Davidge, ST, Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Florian Herse, Ralf Dechend, Dudenhausen, J.W., Nele Geusens, Cartwright, J.E., Geusens, N., Verhaegen, I., Jude Morton, Morton, J, Hering, L, Iris Verhaegen, Dominik N. Muller, Dechend, R., Sandra T. Davidge, Joachim W. Dudenhausen, Hering, L., Davidge, S.T., Verlohren, S, Verhaegen, I, Dudenhausen, JW, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Molecules, 2020
In December 2019, a new severe acute respiratory syndrome coronavirus (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), emerged in Wuhan, China.
Mathieu Gendrot, J. Andreani, Priscilla Jardot, S. Hutter, Océane Delandre, M. Boxberger, J. Mosnier, M. Le Bideau, Isabelle Duflot, Isabelle Fonta, Clara Rolland, H. Bogreau, B. La Scola, B. Pradines   +13 more
semanticscholar   +1 more source

Effect of iron chelation on anti-pseudomonal activity of doxycycline

International Journal of Antimicrobial Agents, 2021
Highlights • High affinity iron chelation enhances the antibacterial activity of tetracyclines.• High affinity iron chelation synergises with doxycycline against P.
M. Faure, A. Cilibrizzi, V. Abbate, K. Bruce, R. Hider   +4 more
semanticscholar   +1 more source

Doxycycline to treat levodopa-induced dyskinesias in Parkinson's disease: a preliminary study

Arquivos de Neuro-Psiquiatria, 2023
Background Levodopa-induced dyskinesia (LID) is a common motor complication of levodopa therapy in patients with Parkinson's disease (PD). Doxycycline is a widely used and inexpensive tetracycline with anti-inflammatory properties.
Bruno Lopes Santos-Lobato, Manuelina Mariana Capellari Macruz Brito, Ângela Vieira Pimentel, Rômulo Torres Oliveira Cavalcanti, Elaine Del-Bel, Vitor Tumas   +5 more
doaj   +1 more source

Doxycycline-induced shRNAs specifically attenuated expression of NF90/NF110 or NF45 proteins.

, 2019
HEK293 cells stably transfected with pINDUCER10-shNF90/NF110 (D2) or pINDUCER10-shNF45 (D5) were treated without or with doxycycline for 96 h, then serum starved for 12 h and treated with PMA (20 ng/ml) for 2 h.
Anson W. Lowe (273580), Mark R. Nicolls (470372), Ting-Hsuan Wu (5028911), Peter N. Kao (74331), Lingfang Shi (74325)   +4 more
core   +1 more source