Results 21 to 30 of about 150,359 (342)

Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts

Molecules, 2021
Zika virus (ZIKV) represents a re-emerging threat to global health due to its association with congenital birth defects. ZIKV NS2B-NS3 protease is crucial for virus replication by cleaving viral polyprotein at various junctions to release viral proteins ...
Teow Chong Teoh, Sawsam J. Al-Harbi, Ammar Yasir Abdulrahman, Hussin A. Rothan   +3 more
doaj   +1 more source

Investigation of a combination therapy approach for the treatment of melioidosis

Frontiers in Microbiology, 2022
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei.
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding, Sarah V. Harding   +9 more
doaj   +1 more source

Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases

Antioxidants, 2022
Excess alcohol consumption is a potential risk factor for cardiovascular diseases and is linked to accelerated aging. Drug discovery to reduce toxic cellular events of alcohol is required.
Xuanchen Li, Dilaware Khan, Majeed Rana, Daniel Hänggi, Sajjad Muhammad   +4 more
doaj   +1 more source

Doxycycline host-directed therapy in human pulmonary tuberculosis.

Journal of Clinical Investigation, 2021
BACKGROUND Matrix metalloproteinases (MMPs) are implicated as key regulators of tissue destruction in tuberculosis (TB) and may be a target for host-directed therapy.
Q. H. Miow, A. Vallejo, Yu Wang, J. Hong, Chen Bai, F. S. Teo, Alvin D.Y. Wang, Hong Loh, T. Tan, Ying Ding, Hoi Wah She, S. Gan, N. Paton, Josephine Lum, Alicia Tay, C. Chee, P. Tambyah, M. Polak, Ye Wang, Amit Singhal, P. Elkington, J. Friedland, C. Ong   +22 more
semanticscholar   +1 more source

Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects

Pulmonary Pharmacology & Therapeutics, 2021
Coronavirus virus disease 2019 (COVID-19) is a viral infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually considered as a global pandemic.
H. Al-kuraishy, A. Al-Gareeb, Naeem F Qusty, N. Cruz-Martins, Gaber El-Saber Batiha   +4 more
semanticscholar   +1 more source

The inhibitory effect of doxycycline on cisplatin-sensitive and -resistant epithelial ovarian cancer.

PLoS ONE, 2014
BackgroundDetecting a new effective and hypotoxic anticancer drug is an emerging new strategy for cancer chemotherapy. Doxycycline (DC) is a kind of antibiotics but also inhibits tumorigenesis.MethodsMTT and cell invasion assay, flow cytometry, western ...
Wei Wu, Li-Hua Yu, Bei Ma, Ming-Juan Xu
doaj   +1 more source

Azithromycin or Doxycycline for Asymptomatic Rectal Chlamydia trachomatis.

New England Journal of Medicine, 2021
BACKGROUND Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from randomized, controlled trials are needed to guide treatment.
Andrew Lau, F. Kong, C. Fairley, D. Templeton, J. Amin, S. Phillips, M. Law, Marcus Y. Chen, C. Bradshaw, B. Donovan, A. McNulty, M. Boyd, P. Timms, E. Chow, D. Regan, C. Khaw, D. Lewis, J. Kaldor, M. Ratnayake, N. Carvalho, J. Hocking   +20 more
semanticscholar   +1 more source

Tetracycline Actions Relevant to Rosacea Treatment [PDF]

, 2009
Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Schöllmann, C., Korting, Hans Christian, C. Schöllmann, H.C. Korting   +3 more
core   +1 more source

Effect of Doxycycline on Aneurysm Growth Among Patients With Small Infrarenal Abdominal Aortic Aneurysms: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Abdominal aortic aneurysms affect more than 3% of US older adults. Objective To test whether doxycycline reduces the growth of abdominal aortic aneurysm over 2 years as measured by maximum transverse diameter.
B. Baxter, J. Matsumura, J. Curci, R. Mcbride, L. Larson, W. Blackwelder, D. Lam, M. Wijesinha, M. Terrin, Nih Investigators   +9 more
semanticscholar   +1 more source

Doxycycline as a potential partner of COVID-19 therapies

IDCases, 2020
Coronavirus disease 2019 (COVID-19) is a major public health challenge, and the current antiviral arsenal for treatment is limited, with questionable efficacy.
A. Malek, B. Granwehr, D. Kontoyiannis
semanticscholar   +1 more source