Results 21 to 30 of about 124,618 (258)

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation

Journal of International Medical Research, 2021
Objectives The anti-cancer activity of doxycycline has been reported in many cancers but not renal cell carcinoma (RCC). This study aimed to determine the efficacy of doxycycline alone and in combination with paclitaxel and analyze the underlying ...
Bo Wang, Jinsong Ao, Xiaoyan Li, Weimin Yu, Dan Yu, Chengjun Qiu   +5 more
doaj   +1 more source

Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. [PDF]

PLoS ONE, 2012
There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being investigated is the use of doxycycline. Despite being primarily used as an antimicrobial drug, doxycycline
Xiaojie Xie, Hong Lu, Jessica J Moorleghen, Deborah A Howatt, Debra L Rateri, Lisa A Cassis, Alan Daugherty   +6 more
doaj   +1 more source

Dengue and Scrub Typhus Coinfection: A Diagnostic Dilemma

Oman Medical Journal, 2023
Due to overlapping clinical features, scrub typhus infection may be missed in presence of dengue. Concurrent infection with those two pathogens is rare and creates a diagnostic dilemma. We present a case of a 65-year-old male who was admitted with a high-
Atanu Chandra, Arkapravo Hati, Aritra Kumar Ray, Uddalak Chakraborty, Partha Sarathi Karmakar, Sugata Dasgupta   +5 more
doaj   +1 more source

Doxycycline as an initial treatment of bullous pemphigoid in Japanese patients

Journal of Cutaneous Immunology and Allergy, 2020
Objectives Tetracycline antibiotics have been used in bullous pemphigoid (BP) for their anti‐inflammatory effects. In Japan, tetracycline and minocycline, but not doxycycline, have been generally used in BP, although doxycycline has a better side‐effect ...
Kiyoto Kimura, Kazuhiro Kawai
doaj   +1 more source

Doxycycline to treat levodopa-induced dyskinesias in Parkinson's disease: a preliminary study

Arquivos de Neuro-Psiquiatria, 2023
Background Levodopa-induced dyskinesia (LID) is a common motor complication of levodopa therapy in patients with Parkinson's disease (PD). Doxycycline is a widely used and inexpensive tetracycline with anti-inflammatory properties.
Bruno Lopes Santos-Lobato, Manuelina Mariana Capellari Macruz Brito, Ângela Vieira Pimentel, Rômulo Torres Oliveira Cavalcanti, Elaine Del-Bel, Vitor Tumas   +5 more
doaj   +1 more source

Doxycycline-induced bioluminescence in the mammary gland of the MTB/Cat^TMILA bigenic.

, 2017
(A) Overlay of full-body bioluminescence and x-ray images of monogenic control (G6719 (ear tag#)) and MTB/CatTMILA bigenic (G6718 (ear tag#)) mice following 0, 24, and 48 hours of doxycycline intake.
Maria M. Szwarc (476339), Lan Hai (3808492), John P. Lydon (476343), Ramakrishna Kommagani (476338), David M. Lonard (554019), Mary C. Peavey (2585938)   +5 more
core   +1 more source

The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

, 2021
Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline-which belongs to the tetracycline class-reduces mitochondrial function, and results in ...
Tazehkandi, V.A., Coolen, B.F., Strijkers, G.J., Baks‐Te Bulte, L., Kuster, D.W.D., Wüst, R.C.I.; id_orcid, Wiersma, M., Daal, M.R.R., Brundel, B.J.J.M., van Weeghel, M., Held, N.M., Houtkooper, R.H., Vida Alizadeh Tazehkandi, Luciënne Baks-te Bulte, Ntsiki M. Held, Marit Wiersma, Rob C. I. Wüst, Michel van Weeghel, Mariah R. R. Daal, Diederik W. D. Kuster, Gustav J. Strijkers, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Bram F. Coolen   +23 more
core   +2 more sources

Doxycycline-induced shRNAs specifically attenuated expression of NF90/NF110 or NF45 proteins.

, 2019
HEK293 cells stably transfected with pINDUCER10-shNF90/NF110 (D2) or pINDUCER10-shNF45 (D5) were treated without or with doxycycline for 96 h, then serum starved for 12 h and treated with PMA (20 ng/ml) for 2 h.
Anson W. Lowe (273580), Mark R. Nicolls (470372), Ting-Hsuan Wu (5028911), Peter N. Kao (74331), Lingfang Shi (74325)   +4 more
core   +1 more source

Doxycycline-induced fixed drug eruption: A case series highlighting a dermatological concern in antimicrobial stewardship

International Journal of Infectious Diseases
Objectives: To describe a series of doxycycline-induced fixed drug eruptions (FDE) observed in sexual health clinics, in a context of increasing doxycycline use for sexually transmitted infection (STI) management and prophylaxis in France.
Clément Brun, Marie Danset, Romain Salle, Victor Bourdenet, Louise Jaulent, Florence Hacard, Marine Fargeas, Brigitte Milpied, Elisa Goujon, Valérie Beaulieu, Timothy Capeliez, Sébastien Fouéré, Matthieu Godinot, Marie Tauber   +13 more
doaj   +1 more source

Doxycycline Proniosomal Gel as Local Drug Delivery System in Periodontal Disease: A Vitro Study

Journal of Pharmacy and Bioallied Sciences
Background: Periodontitis is an inflammatory condition of the oral cavity in which microorganisms play a significant role in the pathogenesis and onset.
Dhawal Rajendra Mody, Vrushali Lathiya, Abhay P. Kolte, Vaishnavi Biradar, Vaishnavi Langde   +4 more
doaj   +1 more source