Results 21 to 30 of about 159,147 (288)
Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]
, 2016 Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G. +4 more
core +1 more source
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice. [PDF]
PLoS ONE, 2012 There is no proven medical approach to attenuating expansion and rupture of abdominal aortic aneurysms (AAAs). One approach that is currently being investigated is the use of doxycycline. Despite being primarily used as an antimicrobial drug, doxycycline
Xiaojie Xie +6 more
doaj +1 more source
Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin [PDF]
, 2012 Background: The gastrointestinal tract is the first target for the potentially harmful effects of mycotoxins after intake of mycotoxin contaminated food or feed.
Croubels, Siska +8 more
core +2 more sources
Neurobiology of Disease, 2009 Doxycycline, a tetracycline antibiotic inhibits matrix metalloproteinase (MMP) and reduces neuronal damage in focal brain ischemia. This study was undertaken to assess if doxycycline reduces delayed neuronal damage following transient global cerebral ...
Hyung Lee +4 more
doaj +1 more source
Doxycycline as an initial treatment of bullous pemphigoid in Japanese patients
Journal of Cutaneous Immunology and Allergy, 2020 Objectives Tetracycline antibiotics have been used in bullous pemphigoid (BP) for their anti‐inflammatory effects. In Japan, tetracycline and minocycline, but not doxycycline, have been generally used in BP, although doxycycline has a better side‐effect ...
Kiyoto Kimura, Kazuhiro Kawai
doaj +1 more source
Frontiers in Microbiology, 2023 BackgroundFour randomized controlled trials have now established that doxycycline post exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men who have sex with men.
Chris Kenyon +9 more
doaj +1 more source
Journal of International Medical Research, 2021 Objectives The anti-cancer activity of doxycycline has been reported in many cancers but not renal cell carcinoma (RCC). This study aimed to determine the efficacy of doxycycline alone and in combination with paclitaxel and analyze the underlying ...
Bo Wang +5 more
doaj +1 more source
BMC Infectious Diseases, 2012 Background Persistent symptoms after treatment of neuroborreliosis (NB) are well-documented, although the causative mechanisms are mainly unknown. The effect of repeated antibiotic treatment has not been studied in detail.
Sjöwall Johanna +4 more
doaj +1 more source
Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo
Neurobiology of Disease, 2021 Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn).
Antonio Dominguez-Meijide +13 more
doaj +1 more source