Results 1 to 10 of about 158,998 (164)

Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

Journal of Cardiovascular Development and Disease, 2022
Aim: Evaluate the influence of doxycycline, an anti-inflammatory and matrix metalloproteinase (MMP) inhibitor, on the attenuation of chronic doxorubicin-induced cardiotoxicity in rats. Methods: We allocated male Wistar rats into four groups: control (C),
Danielle Dantas, Amanda Gomes Pereira, Anderson Seiji Soares Fujimori, Ana Paula Dantas Ribeiro, Carol Cristina Vágula de Almeida Silva, Marina Gaiato Monte, Camila Renata Corrêa, Ana Angélica Fernandes, Silmeia Garcia Zanati Bazan, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Sergio Alberto Rupp de Paiva, Leonardo Antônio Mamede Zornoff, Bertha Furlan Polegato   +13 more
doaj   +1 more source

Doxycycline in STI Prophylaxis—A Literature Review

Venereology, 2023
Background: Since the implementation of pre-exposure prophylaxis (PrEP) in HIV prevention, a significant increase in the prevalence of other sexually transmitted infections (STIs) has been reported, especially among men who have sex with men (MSM ...
Andrzej Załęski, Mariusz Sapuła, Agnieszka Lembas, Alicja Wiercińska-Drapało   +3 more
doaj   +1 more source

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial. [PDF]

PLoS Neglected Tropical Diseases, 2010
The risk of severe adverse events following treatment of onchocerciasis with ivermectin in areas co-endemic with loiasis currently compromises the development of control programmes and the treatment of co-infected individuals.
Joseph D Turner, Nicholas Tendongfor, Mathias Esum, Kelly L Johnston, R Stuart Langley, Louise Ford, Brian Faragher, Sabine Specht, Sabine Mand, Achim Hoerauf, Peter Enyong, Samuel Wanji, Mark J Taylor   +12 more
doaj   +1 more source

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2022
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers.
Yi-Fong Chen, Yi-Fong Chen, Yung-Ning Yang, Yung-Ning Yang, Hung-Ru Chu, Hung-Ru Chu, Tung-Yung Huang, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Han-Yu Chen, Zi-Lin Li, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Paul J. Davis   +23 more
doaj   +1 more source

Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection?

Pathogens and Immunity, 2022
Background:  Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficileinfection, but the microbiologic explanation for this finding is unclear.
Dongyan Xu, Thriveen Mana, Jennifer Cadnum, Abhishek Deshpande, Faezeh Afsari, Naseer Sangwan, Curtis Donskey   +6 more
doaj   +1 more source

Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer

Journal of Chemistry, 2021
In the current study, we aim to evaluate the effect of the combination of silver and doxycycline (silver-doxycycline complex) on the viability of the MCF-7 cell line of the breast in comparison with each of them.
Vahid Mohammadkarimi, Negar Azarpira, Zahra Ghanbarinasab, Pezhman Shiri, Fatemeh Sadat Dehghani, Amin Nakhostin-Ansari, Fatemeh Tayyebi-Khorrami, Amir Atapour, Ali Mohammad Amani   +8 more
doaj   +1 more source

Investigation of a combination therapy approach for the treatment of melioidosis

Frontiers in Microbiology, 2022
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei.
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding, Sarah V. Harding   +9 more
doaj   +1 more source

Rumen Microbiota Distribution Analyzed by High-Throughput Sequencing After Oral Doxycycline Administration in Beef Cattle

Frontiers in Veterinary Science, 2020
The beef cattle rumen is a heterogenous microbial ecosystem that is necessary for the host to digest food and support growth. The importance of the rumen microbiota (RM) is also widely recognized for its critical roles in metabolism and immunity.
Fengmei Chen, Guangmin Cheng, Yulin Xu, Yulin Xu, Yulin Xu, Yulin Xu, Yunzhou Wang, Qingxiang Xia, Shilin Hu   +8 more
doaj   +1 more source

Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases

Antioxidants, 2022
Excess alcohol consumption is a potential risk factor for cardiovascular diseases and is linked to accelerated aging. Drug discovery to reduce toxic cellular events of alcohol is required.
Xuanchen Li, Dilaware Khan, Majeed Rana, Daniel Hänggi, Sajjad Muhammad   +4 more
doaj   +1 more source

Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. [PDF]

, 2018
Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2).
Aguayo, Esteban, Baker, Anthony J, Collins, Alexander, Faraji, Farshid, Ge, Liang, Lovett, David H, Ratcliffe, Mark B, Saloner, David, Spaulding, Kimberly, Takaba, Kiyoaki, Wallace, Arthur W, Wang, Guanying   +11 more
core   +6 more sources