Results 11 to 20 of about 150,359 (342)

Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections

New England Journal of Medicine, 2023
BACKGROUND Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed. METHODS We conducted an open-label, randomized study involving MSM and transgender women who were taking preexposure prophylaxis ...
A. Luetkemeyer, D. Donnell, Julia C. Dombrowski, S. Cohen, Cole Grabow, Clare E. Brown, C. Malinski, R. Perkins, Melody Nasser, C. López, E. Vittinghoff, S. Buchbinder, H. Scott, E. Charlebois, D. Havlir, O. Soge, C. Celum   +16 more
semanticscholar   +1 more source

Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women

New England Journal of Medicine, 2023
BACKGROUND Doxycycline postexposure prophylaxis (PEP) has been shown to prevent sexually transmitted infections (STIs) among cisgender men and transgender women, but data from trials involving cisgender women are lacking.
Jenell Stewart, K. Oware, Deborah Donnell, Lauren R. Violette, J. Odoyo, O. Soge, Caitlin W Scoville, Victor Omollo, F. Mogaka, F. A. Sesay, R. S. McClelland, Matthew Spinelli, Monica Gandhi, E. Bukusi, J. Baeten   +14 more
semanticscholar   +1 more source

Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus.

New England Journal of Medicine, 2023
BACKGROUND The appropriate antibiotic treatment for severe scrub typhus, a neglected but widespread reemerging zoonotic infection, is unclear. METHODS In this multicenter, double-blind, randomized, controlled trial, we compared the efficacy of ...
G. Varghese, D. Dayanand, Karthik Gunasekaran, Debasree Kundu, Mukta Wyawahare, Navneet Sharma, D. Chaudhry, S. Mahajan, K. Saravu, B. Aruldhas, B. Mathew, Roshini G Nair, N. Newbigging, A. Mathew, K. Abhilash, M. Biswal, A. Prasad, A. Zachariah, R. Iyadurai, S. Hansdak, S. Sathyendra, T. Sudarsanam, J. A. J. Prakash, A. Manesh, A. Mohan, J. Tarning, S. Blacksell, Pimnara Peerawaranun, Naomi Waithira, M. Mukaka, P. Cheah, J. Peter, O. Abraham, N. Day   +33 more
semanticscholar   +1 more source

Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections

Journal of Antimicrobial Chemotherapy, 2023
Rates of sexually transmitted infections (STIs) continue to rise across the world and interventions are essential to reduce their incidence. Past and recent studies have indicated this may be achieved using doxycycline post-exposure prophylaxis (PEP) and
F. Kong, C. Kenyon, M. Unemo
semanticscholar   +1 more source

Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline

Microbiology spectrum, 2023
Doxycycline is an important broad-spectrum tetracycline antibiotic used for treating multiple human infections, but its resistance rates are recently rising globally.
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li   +8 more
semanticscholar   +1 more source

Safety of longer-term doxycycline use: A systematic review and meta-analysis with implications for bacterial STI chemoprophylaxis

Sexually Transmitted Diseases, 2023
A systematic review of longer-term doxycycline (8+ weeks) found that the medication was generally well tolerated and safe. Findings have implications for doxycycline as chemoprophylaxis for the prevention of sexually transmitted infections.
Philip A. Chan, Danielle L Le Brazidec, Jeffrey S. Becasen, Harrison Martin, Jhanavi Kapadia, Hilary Reno, Laura H. Bachmann, L. Barbee   +7 more
semanticscholar   +1 more source

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

The Lancet Respiratory Medicine, 2021
Background Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use.
C. Butler, Ly-Mee Yu, J. Dorward, O. Gbinigie, G. Hayward, B. Saville, O. van Hecke, N. Berry, M. Detry, Christina T. Saunders, M. Fitzgerald, V. Harris, R. Djukanović, S. Gadola, J. Kirkpatrick, S. de Lusignan, E. Ogburn, P. Evans, Nicholas P. B. Thomas, Mahendra G Patel, F. R. Hobbs   +20 more
semanticscholar   +1 more source

Doxycycline prevents blood–brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury

Scientific Reports, 2022
The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection against secondary injuries following traumatic brain injury (TBI).
B. Robinson, C. Isbell, A. Melge, Angela M. Lomas, C. A. Shaji, C. G. Mohan, Jason H. Huang, B. Tharakan   +7 more
semanticscholar   +1 more source

Rumen Microbiota Distribution Analyzed by High-Throughput Sequencing After Oral Doxycycline Administration in Beef Cattle

Frontiers in Veterinary Science, 2020
The beef cattle rumen is a heterogenous microbial ecosystem that is necessary for the host to digest food and support growth. The importance of the rumen microbiota (RM) is also widely recognized for its critical roles in metabolism and immunity.
Fengmei Chen, Guangmin Cheng, Yulin Xu, Yulin Xu, Yulin Xu, Yulin Xu, Yunzhou Wang, Qingxiang Xia, Shilin Hu   +8 more
doaj   +1 more source

Doxycycline Attenuates Pig Intestinal Microbial Interactions and Changes Microbial Metabolic Pathways

Animals, 2023
Doxycycline is a therapeutic veterinary antibiotic commonly used in pig breeding. In this study, 27 fattening pigs of 33.5 ± 0.72 kg were divided equally into 3 groups.
Jiaojiao Xu, Jiadi Liang, Wenjun Chen, Xin Wen, Na Zhang, Baohua Ma, Yongde Zou, Jiandui Mi, Yan Wang, Xindi Liao, Yinbao Wu   +10 more
doaj   +1 more source