Results 11 to 20 of about 99,202 (246)

Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts

Molecules, 2021
Zika virus (ZIKV) represents a re-emerging threat to global health due to its association with congenital birth defects. ZIKV NS2B-NS3 protease is crucial for virus replication by cleaving viral polyprotein at various junctions to release viral proteins ...
Teow Chong Teoh, Sawsam J. Al-Harbi, Ammar Yasir Abdulrahman, Hussin A. Rothan   +3 more
doaj   +1 more source

Why Does Doxycycline Pose a Relatively Low Risk for Promotion of Clostridioides difficile Infection?

Pathogens and Immunity, 2022
Background:  Clinical studies suggest that doxycycline poses a low risk for promotion of Clostridioides difficileinfection, but the microbiologic explanation for this finding is unclear.
Dongyan Xu, Thriveen Mana, Jennifer Cadnum, Abhishek Deshpande, Faezeh Afsari, Naseer Sangwan, Curtis Donskey   +6 more
doaj   +1 more source

Rumen Microbiota Distribution Analyzed by High-Throughput Sequencing After Oral Doxycycline Administration in Beef Cattle

Frontiers in Veterinary Science, 2020
The beef cattle rumen is a heterogenous microbial ecosystem that is necessary for the host to digest food and support growth. The importance of the rumen microbiota (RM) is also widely recognized for its critical roles in metabolism and immunity.
Fengmei Chen, Guangmin Cheng, Yulin Xu, Yulin Xu, Yulin Xu, Yulin Xu, Yunzhou Wang, Qingxiang Xia, Shilin Hu   +8 more
doaj   +1 more source

Investigation of a combination therapy approach for the treatment of melioidosis

Frontiers in Microbiology, 2022
The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei.
Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding, Sarah V. Harding   +9 more
doaj   +1 more source

Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases

Antioxidants, 2022
Excess alcohol consumption is a potential risk factor for cardiovascular diseases and is linked to accelerated aging. Drug discovery to reduce toxic cellular events of alcohol is required.
Xuanchen Li, Dilaware Khan, Majeed Rana, Daniel Hänggi, Sajjad Muhammad   +4 more
doaj   +1 more source

Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP

Frontiers in Microbiology, 2023
BackgroundFour randomized controlled trials have now established that doxycycline post exposure (sex) prophylaxis (PEP) can reduce the incidence of chlamydia and syphilis in men who have sex with men.
Chris Kenyon, Chris Kenyon, Zina Gestels, Thibaut Vanbaelen, Said Abdellati, Dorien Van Den Bossche, Irith De Baetselier, Basil Britto Xavier, Basil Britto Xavier, Sheeba Santhini Manoharan-Basil   +9 more
doaj   +1 more source

The inhibitory effect of doxycycline on cisplatin-sensitive and -resistant epithelial ovarian cancer.

PLoS ONE, 2014
BackgroundDetecting a new effective and hypotoxic anticancer drug is an emerging new strategy for cancer chemotherapy. Doxycycline (DC) is a kind of antibiotics but also inhibits tumorigenesis.MethodsMTT and cell invasion assay, flow cytometry, western ...
Wei Wu, Li-Hua Yu, Bei Ma, Ming-Juan Xu
doaj   +1 more source

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

Neurobiology of Disease, 2009
Doxycycline, a tetracycline antibiotic inhibits matrix metalloproteinase (MMP) and reduces neuronal damage in focal brain ischemia. This study was undertaken to assess if doxycycline reduces delayed neuronal damage following transient global cerebral ...
Hyung Lee, Jong-Wook Park, Sang-Pyo Kim, Eng H. Lo, Seong-Ryong Lee   +4 more
doaj   +1 more source

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation

Journal of International Medical Research, 2021
Objectives The anti-cancer activity of doxycycline has been reported in many cancers but not renal cell carcinoma (RCC). This study aimed to determine the efficacy of doxycycline alone and in combination with paclitaxel and analyze the underlying ...
Bo Wang, Jinsong Ao, Xiaoyan Li, Weimin Yu, Dan Yu, Chengjun Qiu   +5 more
doaj   +1 more source

Doxycycline-mediated effects on persistent symptoms and systemic cytokine responses post-neuroborreliosis: a randomized, prospective, cross-over study

BMC Infectious Diseases, 2012
Background Persistent symptoms after treatment of neuroborreliosis (NB) are well-documented, although the causative mechanisms are mainly unknown. The effect of repeated antibiotic treatment has not been studied in detail.
Sjöwall Johanna, Ledel Anna, Ernerudh Jan, Ekerfelt Christina, Forsberg Pia   +4 more
doaj   +1 more source