Results 191 to 200 of about 85,599,608 (253)

Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial. [PDF]

Lancet Diabetes Endocrinol, 2023
Laffel LM, Danne T, Klingensmith GJ, Tamborlane WV, Willi S, Zeitler P, Neubacher D, Marquard J, DINAMO Study Group.   +8 more
europepmc   +1 more source

Frailty and low body mass index as key determinants of sodium‐glucose cotransporter 2 inhibitor‐specific adverse event‐related discontinuation in adults aged ≥75 years: A multicenter real‐world retrospective cohort study

Journal of Diabetes Investigation, EarlyView.
Among Japanese adults aged ≥75 years newly initiating SGLT2 inhibitors, SGLT2 inhibitor–specific adverse event‐related discontinuation occurred in 9.1% within 180 days. Frailty and low BMI, rather than chronological age, were the key predictors, highlighting the importance of assessing physiological reserve before treatment initiation.
Taisuke Uchida, Hiroaki Ueno, Ayaka Konagata, Hiroki Nabekura, Yuki Kikuchi, Takumi Beppu, Akari Sekishima, Hirotaka Sekishima, Takayuki Nakamura, Fumiko Kogo, Yudai Uehira, Yuri Tanaka, Hideki Yamaguchi, Kazuya Shimoda   +13 more
wiley   +1 more source

MicroRNAs modulated by DPP-4 inhibitor and bedtime NPH insulin therapy in individuals with type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Santos AS, Bando SY, Correa Giannella MLC, da Silva MER.   +3 more
europepmc   +1 more source

Diabetes attenuates weight reduction‐mediated liver fibrosis regression in persons with morbid obesity

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims Weight loss by laparoscopic sleeve gastrectomy (LSG) compared to medical weight loss (low‐calorie diet: LCD) ameliorates diabetes and metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to evaluate changes in liver pathology 1‐year after LSG and their associations with metabolic factors in Japanese participants with
Daiki Matsubara, Yumie Takeshita, Masahiro Mori, Yujiro Nakano, Kenichi Harada, Noboru Takata, Kengo Hayashi, Hideki Moriyama, Noriyuki Inaki, Masao Honda, Taro Yamashita, Toshinari Takamura   +11 more
wiley   +1 more source

Parasympathetic dysfunction assessed by deep‐breathing CVR‐R is associated with early discontinuation of oral semaglutide in type 2 diabetes: A multicenter retrospective study

Journal of Diabetes Investigation, EarlyView.
Lower CVR‐R during deep breathing (CVR‐R_DB), a marker of parasympathetic function, was associated with early discontinuation of oral semaglutide due to nausea and/or vomiting in patients with type 2 diabetes. CVR‐R_DB may support risk stratification at treatment initiation.
Kazuma Ogiso, Takahisa Deguchi, Shigeru Kawade, Aiko Arimura, Yoshihiko Nishio, Katsutaro Morino   +5 more
wiley   +1 more source

Case Report: NEUROD1 c.-108G>C mutation in a ketosis-prone MODY6 patient: implications for genetic testing and DPP-4 inhibitor therapy. [PDF]

Front Endocrinol (Lausanne)
Shao Z, Xu L.
europepmc   +1 more source

Do Intoxicated Offenders Deserve Harsher Sentences? Questioning Veritas in Vino

Journal of Social Philosophy, EarlyView.
ABSTRACT Criminal courts increasingly treat intoxication as an aggravating rather than a mitigating factor in sentencing. This shift, seen in Australian law and other jurisdictions, raises the prospect of unjust outcomes. We examine this trend through the lens of desert‐based justifications for punishment, setting aside questions of deterrence and ...
Mary Jean Walker, Daniel B. Cohen
wiley   +1 more source

Triple oral therapy with metformin, DPP-4 inhibitor, and SGLT2 inhibitor for adults with type 2 diabetes: Consensus recommendations of a Chinese expert panel (version 2025). [PDF]

Diabetes Obes Metab
Yu M, Wang T, Xu C, Bi Y, Gao L, Wang G, Xiang G, Xue Y, Yang T, Kang D, Zhou Z, Guo L, Xiao X, Steering Committee, Development Group, Diabetes Committee of the Chinese Research Hospital Association.   +15 more
europepmc   +1 more source

Incretin‐Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice

Obesity Reviews, EarlyView.
ABSTRACT Introduction Pregnancy concurrent with incretin‐based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin‐based medications in relation to preconception, pregnancy, and postnatal health, and to propose ...
Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart, Sam Schoenmakers, Amihai Rottenstreich, Heather Hopper, Mojca Jensterle, Angela C. Flynn, Sarah Siegelaar, Annick Bogaerts, Isy Douek, Nicola Heslehurst, Dries Ceulemans, Tricia Tan, Johnathan Pinkney, Martin Whyte, Shahrad Taheri, Roland Devlieger   +19 more
wiley   +1 more source

Euglycemic DKA in a DPP-4 inhibitor patient following traumatic brain injury: A complex ICU glucose management challenge. [PDF]

Medicine (Baltimore)
Shammas I, Seyaj M, Altell K, Sobeih R, Asafrah L, Burqan M, Abuhalawa M, Shahateet M, Itkaidek S.   +8 more
europepmc   +1 more source