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DPP-4 inhibitors: focus on safety
Expert Opinion on Drug Safety, 2014Dipeptidyl peptidase inhibitors (DPP-4-i) are highly selective inhibitors of the enzyme DPP-4. They act by increasing levels of incretin hormones, which have potent effects on insulin and glucagon release, gastric emptying, and satiety. Our goal is to review the safety issues related to DPP-4-i.This review is based upon a PubMed search of the ...
Sri Harsha, Tella, Marc S, Rendell
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DPP-4 Inhibitors in Clinical Practice
Postgraduate Medicine, 2009Type 2 diabetes is a very common worldwide disorder, with major consequences for patients, society, and health care services. Good glycemic control is an important aspect of diabetes management because it has a significant impact on diabetes-related microvascular and possibly macrovascular complications.
Palalau, Anna I. +3 more
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DPP-4 inhibitors and atherosclerosis: The promise
Atherosclerosis, 20130021-9150/$ e see front matter 2013 Elsevier Irela http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.033 The major cause of mortality and morbidity in diabetes is cardiovascular disease (CVD). Novel therapies that have now been introduced for the treatment of diabetes includingmodulation of the Incretin axis with either glucagon like peptide-1 ...
Ishwarlal, Jialal, Mandeep, Bajaj
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Insulin, 2007
Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels.
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Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels.
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Novel DPP-4 Inhibitors Against Diabetes
Future Medicinal Chemistry, 2014DPP-4 specifically degrades the incretin hormone GLP-1 and GIP, both of which are vital modulators of blood glucose homeostasis. Attributed to its potential biological function, DPP-4 inhibition has presently represented an attractive therapeutic strategy for treating diabetes and aroused a significant interest in the pharmaceutical industry.
Yang, Liu, Yongzhou, Hu
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Exploration of the DPP-4 inhibitors with a focus on saxagliptin
Expert Opinion on Pharmacotherapy, 2009Type 2 diabetes (T2DM) has become a worldwide epidemic. Despite a vast array of new compounds to treat T2DM, recommended treatment goals are consistently not achieved in this country thus suggesting a need to increase treatment options.To review the role of DPP-4 inhibitors in treatment of T2DM with an emphasis on saxagliptin.The authors discuss the ...
Jay H, Shubrook +2 more
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The safety of DPP-4 inhibitor and SGLT2 inhibitor combination therapies
Expert Opinion on Drug Safety, 2018Type 2 diabetes (T2D), a multifactorial and chronic disease, requires in an elevated percentage of patients the association of several antidiabetic drugs to achieve optimal glycemic control. Dipeptidyl peptidase-4 inhibitors (DPP-4i) and sodium-glucose cotransporter inhibitors (SGLT2i) are new classes of oral antidiabetic drugs developed over the last ...
María Molina-Vega +3 more
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Nihon rinsho. Japanese journal of clinical medicine, 2015
Now seven compounds of DPP-4 inhibitor are available in Japan. They can be used in any stage of type 2 diabetes if the insulin secretion capacity is retained; first-line choice to third-line choice or combination with insulin therapy. There is no apparent difference in effect of each DPP-4 inhibitor on glycemic control; HbA1c levels are decreased by 0 ...
Shin-Ichi, Harashima, Nobuya, Inagaki
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Now seven compounds of DPP-4 inhibitor are available in Japan. They can be used in any stage of type 2 diabetes if the insulin secretion capacity is retained; first-line choice to third-line choice or combination with insulin therapy. There is no apparent difference in effect of each DPP-4 inhibitor on glycemic control; HbA1c levels are decreased by 0 ...
Shin-Ichi, Harashima, Nobuya, Inagaki
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DPP-4 inhibitors: pharmacological differences and their clinical implications
Expert Opinion on Drug Safety, 2014Recently, incretin-based therapy was introduced for the treatment of type 2 diabetes (T2D). In particular, dipeptidyl peptidase-4 inhibitors (DPP-4i) (sitagliptin, vildagliptin, saxagliptin, linagliptin and alogliptin) play an increasing role in the management of T2D.An extensive literature search was performed to analyze the pharmacological ...
Ceriello A +3 more
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DPP-4 inhibitors: a patent review (2012 – 2014)
Expert Opinion on Therapeutic Patents, 2014Dipeptidyl peptidase 4 (DPP-4) is a serine protease, which catalyzes the hydrolytic process of the amide bond X-Ala or X-Pro at the N-terminus of peptides. This enzyme is involved in the degradation of two incretin hormones glucagon-like peptide-1 and glucose-dependent-insulinotropic polypeptide, which increase the production and release of insulin ...
COSTANTE, ROBERTO +4 more
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