Results 81 to 90 of about 291,495 (261)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Energy transformation and flow topology in an elbow draft tube

Applied and Computational Mechanics, 2012
Paper presents a computational study of energy transformation in two geometrical configurations of Kaplan turbine elbow draft tube. Pressure recovery, hydraulic efficiency and loss coefficient are evaluated for a series of flow rates and swirl numbers ...
Štefan D., Rudolf P., Skoták A., Motyčák L.   +3 more
doaj  

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Fluid–Solid Mixing Transfer Mechanism and Flow Patterns of the Double-Layered Impeller Stirring Tank by the CFD-DEM Method

Energies
The optimization design of the double-layered material tank is essential to improve the material mixing efficiency and quality in chemical engineering and lithium battery production.
Man Ge, Gaoan Zheng
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Research on the Flow Evolution and Runner Force Characteristics of a Pump-Turbine Under Cavitation Effects

Applied Sciences
Pump-turbines are critical for maintaining power grid stability, but they frequently suffer from flow instabilities induced by cavitation due to frequent operating condition changes.
Yanhao Li, Lei Chen, Jianwen Xu, An Yu
doaj   +1 more source

Study of the effects of modified draft tube with inclined conical diffuser on draft tube and upstream region

Journal of Physics: Conference Series
Abstract Various countermeasures including geometry optimization have been proposed and proved to have a huge impact on flow filed within the draft tube in order to mitigate the vortex rope and the induced pressure fluctuations for Francis turbine under part load operation. However, the effect of these approaches on the hydro-dynamics in
Xing Zhou, Quanshui Huang, Xinyi Hu, Xiangyu Dai   +3 more
openaire   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Influence of Load Variation on the Flow Field and Stability of the Francis Turbine

Journal of Marine Science and Engineering
With the development of a power system predominantly reliant on new energy sources, turbine generator sets are increasingly required to operate under wide load conditions, resulting in numerous unstable flow phenomena and substantial economic losses for ...
Shenhui Li, Jiayang Pang, Chengmei Dan, Wenping Xiang, Xutao Yi, Xiaobing Liu   +5 more
doaj   +1 more source