Results 71 to 80 of about 304,926 (297)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Internal flow characteristics in the draft tube of a Francis turbine under different working conditions

Advances in Mechanical Engineering
The Francis turbine stability is impacted significantly by the flow characteristics in its draft tube. In the case of a Francis turbine in a hydropower plant, numerical simulations were undertaken at the maximum and rated heads, respectively, under three
Yuanhang Hou, Xiaobing Liu, Ming Xiao, Haibin Zhang, Yinhui Cai, Yongzhong Zeng, Lei Zou, Jiayang Pang   +7 more
doaj   +1 more source

CFD SIMULATION OF THE HYDRODYNAMICS AND MIXING TIME IN A STIRRED TANK [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2010
Hydrodynamics and mixing efficiency in stirred tanks influence power draw and are therefore important for the design of many industrial processes. In the present study, both experimental and simulation methods were employed to determine the flow fields ...
AOYI OCHIENG, MAURICE S. ONYANGO
doaj  

Vortex rope instabilities in a model of conical draft tube

EPJ Web of Conferences, 2017
We report on experimental studies of the formation of vortex ropes in a laboratory simplified model of hydroturbine draft tube. Work is focused on the observation of various flow patterns at the different rotational speed of turbine runner at fixed flow ...
Skripkin Sergey, Tsoy Mikhail, Kuibin Pavel, Shtork Sergey   +3 more
doaj   +1 more source

Health and Carcinogenic Risk Assessment of Exposure to by-Products of Photocatalytic Degradation of Toluene in a Spouted Bed Reactor with Porous and Non-Porous Draft Tube. [PDF]

Asian Pac J Cancer Prev, 2023
Hesam G, Zendehdel R, Farhang Dehghan S, Moqtaderi H, Jafari MJ.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Flow Field Analysis of Francis Turbine Draft Tube using POD at Design and Part Load Operating Conditions [PDF]

Journal of Applied Fluid Mechanics
The hydraulic turbines, especially Francis turbines, frequently run at part load (PL) conditions to meet the dynamic energy needs. The flow field at the runner exit changes significantly with a change in the operating point.
S. Kumar, M. J. Cervantes, B. K. Gandhi
doaj   +1 more source

Draft tube guide vane system to mitigate pressure pulsations

, 2022
The present study introduces the concept of mitigating pressure pulsations in a hydro-turbine draft tube. The concept refers to using an adjustable guide vane system in the draft tube.
Cervantes, Michel, Cervantes, Michel,, Joy, Jesline,, Joy, Jesline, Raisee, M,, Raisee, M   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Simulation analysis of internal flow field characteristics of high-speed centrifugal pump as a turbine [PDF]

International Journal of Fluid Engineering
The pump as turbine (PAT), utilizing high-speed centrifugal pumps, boasts technical advantages such as low cost, compact structure, and broad flow adaptability.
Chong Zhou, Zunliang Zhang, Chengpeng Wang, Fangxiao Zhao, Xiang Sun   +4 more
doaj   +1 more source