Results 51 to 60 of about 303,426 (257)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of Runner Downstream Structure on the Flow Field in the Draft Tube of a Small-Sized Water Turbine

Applied Sciences
The flow in the draft tube of the water turbine is affected by the upstream flow and the inherent structure accompanied by various undesirable characteristics, affecting the efficient and stable operation of the water turbine. Changing the flow structure
Lingdi Tang, Zanya Wang, Chenjun Zhang, Wei Wang, Shouqi Yuan   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Transient Simulation for a Pumped Storage Power Plant Considering Pressure Pulsation Based on Field Test

Energies, 2019
In this study, fast Fourier transform and inverse transform are adopted for noise reduction filtering the data of load rejection pressure of a single unit in a one-tube, four-unit pumped storage power station. Five-spot triple smoothing method is used to
Lei Zhang, Jian Zhang, Xiaodong Yu, Jiawen Lv, Xiaoying Zhang   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Regimes with periodical pressure pulsation in Francis draft tube

MATEC Web of Conferences, 2017
The paper reports on results of the experimental study of flow and pressure pulsations in a laboratory model of the draft tube of Francis-99 hydro turbine over a broad range of operating regimes. A novelty is the rapid prototyping and 3-d printing of the
Litvinov Ivan, Gorelikov Evgeny, Shtork Sergey   +2 more
doaj   +1 more source

Flow Field Analysis of Francis Turbine Draft Tube using POD at Design and Part Load Operating Conditions [PDF]

Journal of Applied Fluid Mechanics
The hydraulic turbines, especially Francis turbines, frequently run at part load (PL) conditions to meet the dynamic energy needs. The flow field at the runner exit changes significantly with a change in the operating point.
S. Kumar, M. J. Cervantes, B. K. Gandhi
doaj   +1 more source

SIMULATION OF GAS HOLDUP IN A BUBBLE COLUMN WITH A DRAFT TUBE

Chemical Engineering Transactions, 2009
Not available.
Fukuji Yamashita, Yu Miyazaki
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source