Results 31 to 40 of about 304,926 (297)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Manipulation of the swirling flow instability in hydraulic turbine diffuser by different methods of water injection [PDF]
EPJ Web of Conferences, 2018 Vortex rope, which induces substantial pressure pulsations, arises in the draft tube (diffuser) of Francis turbine for off-design operating conditions.
Rudolf Pavel +3 more
doaj +2 more sources
On the Flow in the Curved Draft Tubes
Transactions of the Society of Mechanical Engineers, 1936 高速水車に使用する彎曲形吸出管の模型を多数製作して、メリヂャン流動と案内羽根で旋回流動を與へたものに就て、管内の水力損失を水量によつて比較し、境界層の流線をペンキで描写し、尚吸出管出口の速度分布を測定して、吸出管内の流動を実驗的に研究したものである。
openaire +2 more sources
Hydroynamics of a spouted bed with a draft tube.
KAGAKU KOGAKU RONBUNSHU, 1988 Glass beads of four sizes were fluidized in a spouted bed comprising a 50 mm-diameter transparent acrylic column and a coaxial draft tube. Draft tube diameter, separation distance and particle size were varied and spouting states were observed.It was found that stable spouting occurred when the air velocity in the tube exceeded about 79% of particle ...
Ijichi, Kazuya +2 more
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Werle´–Legendre Separation in a Hydraulic Machine Draft Tube [PDF]
Journal of Fluids Engineering, 2002 The three-dimensional turbulent flow in a compact hydraulic machine elbow draft tube is numerically investigated for several operating conditions, covering an extended range around the best efficiency point. Comparisons with the experimental data are presented as validation.
Mauri, Sebastiano +2 more
openaire +4 more sources
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source