Results 41 to 50 of about 303,426 (257)
Journal of Applied Fluid Mechanics, 2021 The draft tube is one of the main components that integrate a turbine, since it has the function of recovering the residual kinetic energy after the runner by the pressure energy.
A. C. Barkett Botan +3 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Drying of biological materials in a spout-fluid bed with a draft tube [PDF]
Hemijska Industrija, 2002 The possibility of applying a spout-fluid bed with a draft tube and conical bottom was investigated for drying fluid media with a certain content of suspended material was investigated.
Povrenović Dragan S. +1 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Nuclear Energy and Technology, 2015 The paper presents an experimental study into the thermal-hydraulic performance of the VK-300 reactor based on a model of a single draft tube at a pressure of 3.4MPa, various flow rates and the model inlet relative enthalpies of –0.05 to 0.2.
N.P. Serdun +2 more
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Journal of Physics: Conference SeriesAbstract Various countermeasures including geometry optimization have been proposed and proved to have a huge impact on flow filed within the draft tube in order to mitigate the vortex rope and the induced pressure fluctuations for Francis turbine under part load operation. However, the effect of these approaches on the hydro-dynamics in
Xing Zhou +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source