Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Composite Biomimetic Multi-Subsoiler for Drag Reduction and Wear Resistance Simulation and Experimental Validation. [PDF]
Wang X +6 more
europepmc +1 more source
Aqueous Solutions of Associating Poly(acrylamide-co-styrene): A Path to Improve Drag Reduction? [PDF]
Muratspahić E +4 more
europepmc +1 more source
Salt Water Drops Slide Faster: Ionic Modulation of Drop Friction
Salt ions markedly accelerate water drops on conductive substrates coated with nanometer‐thin hydrophobic layers. Across diverse electrolytes and surfaces, higher ion concentration consistently lowers kinetic friction by reducing contact angle hysteresis.
Dongho Shin +6 more
wiley +1 more source
Underwater Drag Reduction Applications and Fabrication of Bio-Inspired Surfaces: A Review. [PDF]
Zheng Z +6 more
europepmc +1 more source
Drag Reduction by Fish-Scale Inspired Transverse Asymmetric Triangular Riblets: Modelling, Preliminary Experimental Analysis and Potential for Fouling Control. [PDF]
Hamilton BW +2 more
europepmc +1 more source
Deformation‐Induced Formation of Stray Grains in Additive Manufacturing of Single Crystals
Stray grain formation severely limits the additive manufacturing of single‐crystal alloys. By integrating in situ synchrotron techniques, ex situ characterization, and multi‐scale multi‐physics modeling, the authors reveal that stray grains originate from dislocations at the solid‐liquid interface, rather than thermal supercooling in conventional ...
Dongsheng Zhang +11 more
wiley +1 more source
Hierarchical Riblet Structures for Enhanced Drag Reduction and Broader Operational Range in Water Pipelines. [PDF]
Mohammadpour Chehrghani M +4 more
europepmc +1 more source
Drag Reduction Technology of Water Flow on Microstructured Surfaces: A Novel Perspective from Vortex Distributions and Densities. [PDF]
Liu C, Wang W, Hu X, Liu F.
europepmc +1 more source
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo +5 more
wiley +1 more source

