Results 111 to 120 of about 2,577,009 (245)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Mu?ziğin Yaratıcı Drama Atölyelerindeki Rolu? ve Planlama Aşamalarında Etkin Kullanımı
Bu çalışma, mu?ziğin yaratıcı drama atölyelerindeki rolu?nu?; ısınma, canlandırma ve değerlendirme aşamalarında etkinliğini ve kullanım önerilerini belirlemeyi amaçlamaktadır. Çalışmada doku?man inceleme yöntemi kullanılmıştır.
Yapalı, Yunus
core +1 more source
Applied Drama in the intersection of education and healing
Education in the NorthThe article aims at exploring how learning in the classroom becomes more engaging and a dynamic transformative experience for the learners when it becomes embodied through drama tools and conventions.
Chetna Mehrotra
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Drama and the culture of challenge
, 2019 Rachel Jacobs shares her study on student engagement within the Drama classroom and their ability to deal with challenges. She provides insight about the challenges faced by Drama students, while drawing upon the various cultural frames that feed into ...
Jacobs, Rachael (R18862)
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Challenges of drama performance assessment
, 2016 As with any subject area, Drama’s inclusion in the secondary curriculum must conform to curriculum policies and procedures, including those related to assessment and certification. In Drama, students’ creative work is assessed formatively and summatively
Jacobs, Rachael (R18862)
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Performance footprints across Australia : assessment in senior secondary drama
, 2010 Australia’s state and territory systems of education inevitably lead to varying interpretations of drama education and assessment. This paper examines the various models of senior secondary Drama performance assessment across Australian states and ...
Jacobs, Rachael (R18862)
core