Vagus Nerve Stimulation in the Treatment of Dravet Syndrome
罕见病研究, 2022 Dravet syndrome is a epileptic syndrome characterized by drug-resistant epilepsy occuring at childhood. It is often accompanied by status epilepticus and cognitive and language impairment appearing gradually as the disease progresses.
LIU Tinghong +4 more
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Does long‐term phenytoin have a place in Dravet syndrome?
Annals of Clinical and Translational Neurology, 2022 Anti‐seizure medications that block sodium channels are generally considered contraindicated in Dravet syndrome. There is, however, considerable debate about the sodium‐channel blocker phenytoin, which is often used for status epilepticus, a frequent ...
George A. Zographos +2 more
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Fenfluramine for seizures in Dravet syndrome and Lennox-Gastaut syndrome: Mechanisms, clinical evidence, safety, and practical integration. [PDF]
Epilepsy Behav RepDevelopmental and epileptic encephalopathies such as Dravet syndrome and Lennox–Gastaut syndrome remain highly drug resistant and are associated with substantial neurodevelopmental, behavioral, and caregiver burdens.
Janszky J, Janszky J, Horváth R.
europepmc +2 more sources
EBioMedicine, 2016 Dravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-function mutation in the voltage-gated sodium channel gene SCN1A.
Mohammad Ali Faghihi +2 more
exaly +3 more sources
What is new in Dravet syndrome? [PDF]
Romanian Journal of Neurology, 2021 The pathology of Dravet syndrome is of particular importance in children. In this article we analyze the involvement of the SCN1A gene in Dravet syndrome, we approach the new treatment strategies in Dravet syndrome.
Lucia M. Sur +5 more
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Impact of the COVID‐19 lockdown on patients and families with Dravet syndrome
Epilepsia Open, 2021 We explored the impact of coronavirus virus 2019 (COVID‐19) pandemic on patients with Dravet syndrome (DS) and their family. With European patient advocacy groups (PAGs), we developed an online survey in 10 languages to question health status, behavior ...
Isabella Brambilla +8 more
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Identification of SCN1A and PCDH19 mutations in Chinese children with Dravet syndrome. [PDF]
PLoS ONE, 2012 BACKGROUND: Dravet syndrome is a severe form of epilepsy. Majority of patients have a mutation in SCN1A gene, which encodes a voltage-gated sodium channel. A recent study has demonstrated that 16% of SCN1A-negative patients have a mutation in PCDH19, the
Anna Ka-Yee Kwong +3 more
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Prevalence of SCN1A-related dravet syndrome among children reported with seizures following vaccination: a population-based ten-year cohort study. [PDF]
PLoS ONE, 2013 OBJECTIVES: To determine the prevalence of Dravet syndrome, an epileptic encephalopathy caused by SCN1A-mutations, often with seizure onset after vaccination, among infants reported with seizures following vaccination.
Nienke E Verbeek +5 more
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Efficacy and safety of fenfluramine in the treatment of Dravet syndrome - literature review
Journal of Education, Health and Sport, 2022 Dravet Syndrome is a severe, drug-resistant, and rare epileptiform disorder that is typically presented in the first year of life in an otherwise healthy child. It is characterized by prolonged seizures that are often resistant to current anti-epileptic
Martyna Stefaniak +5 more
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Guidance on Dravet syndrome from infant to adult care: Road map for treatment planning in Europe
Epilepsia Open, 2022 Dravet syndrome (DS) is a severe, rare, and complex developmental and epileptic encephalopathy affecting 1 in 16 000 live births and characterized by a drug‐resistant epilepsy, cognitive, psychomotor, and language impairment, and behavioral disorders ...
Elena Cardenal‐Muñoz +6 more
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