Results 91 to 100 of about 3,449,599 (284)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Technology and its impact on the expressive content in the pictorial works of the artist Alberto Burri

open access: yesJournal of Architecture, Art & Humanistic Science
echnique and its impact on the expressive content in the figurative works of the artist Alberto Puri It deals with artistic research and its impact on the expressive content in the figurative works of the artist Alberto Bori, where the war constituted a ...
Lecturer. hajar Al-Sayid Muhamad Al-Ghobari
doaj   +1 more source

The Colossus of Mussolini

open access: yesHistories
In 1933, Renato Ricci, President of the Opera Nazionale Balilla, proposed to move the place of Benito Mussolini’s gatherings from Piazza Venezia to the slopes of Monte Mario, into the Foro Mussolini, a complex mainly dedicated to sport activities.
Fabio Colonnese, Marco Giunta
doaj   +1 more source

Megalomaniacal Plans

open access: yesDrawing On, 2019
If there is one drawing indispensable to the description and production of architecture it is the plan. As it slices through space and substance, it allows us to describe and communicate the partis, construction and circulation of a building, all with ...
Rachel Hurst
doaj   +1 more source

Drawing Drawings: Toward a Narrative Architecture

open access: yesArchitecture Image Studies, 2020
This introductory article opens the subject matter of the second issue of AIS, Narrative Architecture. Drawings have always contained the possibility of being more radical than the architecture they represent. Given the status of architecture within the current building industry, architecture needs to be oppositional to the values of laissez-faire ...
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Overall Buckling Behavior and Design of Steel Stiffened Box Section Columns Under Axial Compression

open access: yesBuildings
This study experimentally and numerically investigated the overall buckling behavior of steel box column components. Two box section specimens were fabricated for axial compression tests.
Bing Shangguan   +5 more
doaj   +1 more source

Anexact but Rigorous

open access: yesDrawing On, 2018
Anexact but Rigorous offers an analytical redrawing of the plans of a series of recent projects by Kazuyo Sejima and Ryue Nishizawa. It describes generative geometrical operations common to these projects and, in turn, articulates a set of recurring ...
Miguel Paredes Maldonado
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Prologue: Of 'Things Between Things'

open access: yesDrawing On, 2018
Read online at: https://drawingon.org/Issue-02-PR-Things-Between ...
Chris French, Piotr Lesniak
doaj   +1 more source

Home - About - Disclaimer - Privacy