Results 71 to 80 of about 576,367 (247)

Points of Departure

open access: yesDrawing On, 2015
This paper describes a project entitled Points of Departure, which forms part of a practice-led research investigation into how existing urban space might be both read and written using fiction, narrative and physical interventions.
Thomas Rivard
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Employing Ergonomic Standards in designing Educational Laboratory for Hand weaving

open access: yesالمجلة الدولية للعلوم الإنسانية والاجتماعية
Occupational safety is considered one of the fundamentals of the success of educational system, especially in light of the remarkable development in the Industrial Revolution and the change it brought in study patterns and educational strategies that ...
Dr. Hala Yousef Al-Osailan
doaj   +1 more source

The House of Multiple Dimensions

open access: yesDrawing On, 2015
This paper explores referencing as a creative practice in order to visually describe the role of references in the development of a design research project.
Ersi Ioannidou
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Introduction: On Drawing On

open access: yesDrawing On, 2015
Read online at: https://drawingon.org/Issue-01-IN ...
Chris French
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

The Colossus of Mussolini

open access: yesHistories
In 1933, Renato Ricci, President of the Opera Nazionale Balilla, proposed to move the place of Benito Mussolini’s gatherings from Piazza Venezia to the slopes of Monte Mario, into the Foro Mussolini, a complex mainly dedicated to sport activities.
Fabio Colonnese, Marco Giunta
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Overall Buckling Behavior and Design of Steel Stiffened Box Section Columns Under Axial Compression

open access: yesBuildings
This study experimentally and numerically investigated the overall buckling behavior of steel box column components. Two box section specimens were fabricated for axial compression tests.
Bing Shangguan   +5 more
doaj   +1 more source

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