Results 61 to 70 of about 3,449,599 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

ArtStroke-GAN: A Unified Framework for Interpreting Watercolor Aesthetics via Personalized Stroke-Based Graphic Language

IEEE Access
Painting is an expressive art form traditionally associated with considerable technical skill and prolonged training, making it largely inaccessible to the general public.
Laixi Zheng
doaj   +1 more source

The City as a School

Drawing On, 2020
‘The City as a School’ describes an urban pedagogy, an approach to design teaching and research that leaves the exclusivity of the school as a space apart, and the safety of a discrete studio-based project behind, to immerse students and teachers in the ...
Kathy Waghorn, Nick Sargent
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Drawing Big Graphs using Spectral Sparsification

, 2017
Spectral sparsification is a general technique developed by Spielman et al. to reduce the number of edges in a graph while retaining its structural properties.
Eades, Peter, Hong, Seok-Hee, Nguyen, Quan   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Recognizing and Drawing IC-planar Graphs

, 2015
IC-planar graphs are those graphs that admit a drawing where no two crossed edges share an end-vertex and each edge is crossed at most once. They are a proper subfamily of the 1-planar graphs.
C Auer, C Auer, C Binucci, C Thomassen, D Král, E Ackerman, E Giacomo Di, E Giacomo Di, E Giacomo Di, EN Argyriou, FJ Brandenburg, H Fraysseix de, J Fox, J Pach, M Chrobak, MA Bekos, MJ Alam, MR Garey, O Cheong, OV Borodin, P Eades, S Hong, S-H Hong, VP Korzhik, W Didimo, W Didimo, X Zhang, X Zhang   +27 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Experimental Evaluation of Book Drawing Algorithms

, 2017
A $k$-page book drawing of a graph $G=(V,E)$ consists of a linear ordering of its vertices along a spine and an assignment of each edge to one of the $k$ pages, which are half-planes bounded by the spine. In a book drawing, two edges cross if and only if
Klawitter, Jonathan, Mchedlidze, Tamara, Nöllenburg, Martin   +2 more
core   +2 more sources