Results 51 to 60 of about 11,722,818 (244)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Sketching as a communication tool and a vehicle for exploring new ideas in Higher Education of industrial design. Implementation and analysis of new methodologies

open access: yesMultidisciplinary Journal for Education, Social and Technological Sciences, 2017
Freehand drawing is a basic tool to explore shapes and visualize ideas during the first phase of projective process in industrial design. Sketches, expressive and quickly executed, allow designers to highlight the most interesting aspects of the product ...
José Luis Navarro   +1 more
doaj   +1 more source

A graph rewriting programming language for graph drawing [PDF]

open access: yes, 1998
This paper describes Grrr, a prototype visual graph drawing tool. Previously there were no visual languages for programming graph drawing algorithms despite the inherently visual nature of the process.
Rodgers, Peter
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

FEM SIMULATION OF DEEP DRAWING PROCESS OF ALUMINIUM ALLOYS [PDF]

open access: yesApplied Computer Science, 2015
This paper presents results of research with FEM simulation of sheet metal forming process. The two types of aluminium alloys from 5XXX and 6XXX series, which are used in automotive industry, were compared.
Jan SLOTA   +4 more
doaj  

The Analysis of “Hot” Drawing Process of Trip Steel Wires at Different Initial Temperatures

open access: yesArchives of Metallurgy and Materials, 2016
In the work the results of preliminary research of the „hot” drawing process of TRIP steel wires at different initial temperatures has been shown.
Wiewiórowska S.   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

DETERMINATION OF POSSIBLE REASONS OF DEFECT FORMATION «MICROPITTING» IN HARD-ALLOY WIRE DRAWING INSTRUMENT IN WIRE DRAWING PROCESS

open access: yesЛитьë и металлургия, 2011
It is determined that during operation a hard wear along with uniform attrition occurs in working canal of die because of welding of metal particles to the material of die, what results in formation of separate microholes, their enlargement and further ...
T. P. Kurenkova   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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