A noncanonical role for Jagged1 in endothelial mechanotransduction
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez +7 more
wiley +1 more source
Assessment of allopurinol use in patients with chronic kidney disease and asymptomatic hyperuricemia: a retrospective cohort study. [PDF]
Souza MELS +4 more
europepmc +1 more source
The raphe nuclear organization and serotonergic system in the bat (Artibeus planirostris)
Schematic representation of the methodological workflow used to characterize the serotonergic (5‐HT) system in the bat Artibeus planirostris. Serotonin (5‐HT) immunohistochemistry was performed on brainstem sections to identify and map the distribution of serotonergic neurons within the raphe nuclei.
Mariana D. Leite +9 more
wiley +1 more source
Patients with chronic kidney disease stage 3b: do general practitioners and nephrologists follow KDIGO guidelines? [PDF]
Macedo JG +3 more
europepmc +1 more source
Continuing displacement in DRC
Despite successful elections in late 2006 and an overall increase in the level of stability, over a million people remain displaced in the east of the Democratic Republic of Congo (DRC). The situation is particularly worrying in North Kivu where over a hundred thousand people have been displaced in recent months.
openaire +1 more source
Abstract When common‐pool resources such as freshwater, clean air, and fisheries span national borders, the collective action problems encountered are particularly severe. This study explores the role of polycentric governance systems in overcoming these pressing problems, which frequently underlie global grand challenges. Integrating political economy
Amol M. Joshi +4 more
wiley +1 more source
Diagnostic performance of contrast-enhanced voiding ultrasonography and direct radionuclide cystography with physiologic bladder filling volumes in pediatric vesicoureteral reflux-a prospective study. [PDF]
Viljamaa HR +5 more
europepmc +1 more source
Abstract A core drilled through shocked and faulted Archean granitoid gneisses and dolerites in the eroded peak ring of the 70–80 km diameter Morokweng impact structure intersects multiple centimeter‐ to meter‐wide clastic‐matrix breccias containing a polymict clast population of lithic and mineral clasts and altered, millimeter‐ to centimeter ‐size ...
Roger L. Gibson +3 more
wiley +1 more source
Triple Burden in the Democratic Republic of Congo: Climate Change, Armed Conflict, and the Silent Spread of Arboviruses. A Narrative Review. [PDF]
Donnang S +8 more
europepmc +1 more source
Measuring the Impact of Armed Conflict on Population Health: A Guide for Researchers
Abstract The humanitarian impact of armed conflict remains a significant international issue, with an estimated 2 billion people residing in fragile or conflict‐affected settings. Despite increasing attention and study of armed conflict and its impact on human populations, few studies have evaluated the methods necessary to assess such relationships ...
Maya Luetke +2 more
wiley +1 more source

