Results 121 to 130 of about 5,304,999 (294)

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

[Blood sampling using "dried blood spot": a clinical biology revolution underway?].

, 2015
International audienceBlood testing using the dried blood spot (DBS) is used since the 1960s in clinical analysis, mainly within the framework of the neonatal screening (Guthrie test).
Lehmann, Sylvain, Hirtz, Christophe
core   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Development of Dried Blood Spot Proficiency Testing Materials for Newborn Screening of Lysosomal Diseases Using Recombinant Enzymes

International Journal of Neonatal Screening
Lysosomal diseases (LDs, or Lysosomal Storage Disorders) have become increasingly visible in the newborn screening community, with the addition of mucopolysaccharidosis type II (MPS-II) into the Recommended Uniform Screening Panel in August 2022 and ...
Elya Courtney, Samantha L. Isenberg, Timothy Lim, C. Austin Pickens, Rachel Lee, Carla Cuthbert, Konstantinos Petritis   +6 more
doaj   +1 more source

The Use of Dried Blood Spot Samples in the Diagnosis of Lysosomal Storage Disorders - Current Status and Perspectives

, 2012
Dried blood spot (DBS) methods are currently available for identification of a range of lysosomal storage disorders ( LSDs). These disorders are generally characterized by a deficiency of activity of a lysosomal enzyme and by a broad spectrum of ...
HWU, WUH-LIANG, 胡務亮
core  

Targeted metabolomics of dried blood spot extracts.

, 2013
Dried blood spot (DBS) samples are already successfully used in newborn screening and pharmacological analyses. The application of DBS matrix to further metabolomic methods will considerably extend the analytical options for the diagnostics of metabolic ...
Prehn, C., Sorgenfrei, M., Adamski, J., Zukunft, S., Möller, G.   +4 more
core   +1 more source

Dried Blood Spots May Offer Route to Wider Antibody Testing [PDF]

JAMA, 2020
openaire   +2 more sources

A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology

Nature Medicine
Abstract Blood biomarkers have emerged as accurate tools for detecting Alzheimer’s disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis.
Hanna Huber, Laia Montoliu-Gaya, Wagner S. Brum, Jakub Vávra, Yara Yakoub, Haley Weninger, Luisa Sophie Braun-Wohlfahrt, Joel Simrén, Mercé Boada, Agustín Ruiz, Amanda Cano, Adelina Orellana, Sergi Valero, Laia Cañada, Natalia Tantinya, Ana Belen Nogales, Pilar Sanz-Cartagena, Anna Dittrich, Ingmar Skoog, Millie Sander-Long, Clive Ballard, Megan Richards, Mary O’Leary, Frederikke Kragh Clemmensen, Hannah H. D. Wandall, Daniele Altomare, Valentina Cantoni, Erik Stomrud, Sebastian Palmqvist, Alberto Lleo, Daniel Alcolea, Maria Carmona Iragui, Aida Sanjuan Hernandez, Bessy Benejam, Laura Videla Toro, Alpana Singh, Marisa N. Denkinger, Anja Hviid Simonsen, Silke Kern, Anne Corbett, Juan Fortea, Lee Honigberg, Barbara Borroni, Oskar Hansson, Xavier Morató, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton   +47 more
openaire   +4 more sources

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

Improving access to rare disease diagnostics in Africa: insights from a multinational pilot study

Orphanet Journal of Rare Diseases
Background Rare diseases (RDs) in Africa face challenges such as limited diagnosis, expertise, and treatment. FYMCA Medical Ltd., the International Gaucher Alliance (IGA) and the Centre for Human Metabolomics (CHM) at North‒West University (NWU) launched
Albe Carina Swanepoel, Christian Johannes Hendriksz, Renson Mukhwana, Abiola Oduwole, Asmahan T. Abdalla, Emmanuel Ameyaw, Kandi-Catherine Muze, Andrew Auruku, Felix Pinto, Dipesalema Joel, Vesna Aleksovska, Tanya Collin-Histed, Roselyn Odero, Engela Helena Conradie   +13 more
doaj   +1 more source