Results 71 to 80 of about 132,121 (307)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

State of the Science in Dried Blood Spots [PDF]

Clinical Chemistry, 2018
AbstractBACKGROUNDAdvancements in the quality and availability of highly sensitive analytical instrumentation and methodologies have led to increased interest in the use of microsamples. Among microsamples, dried blood spots (DBS) are the most well-known. Although there have been a variety of review papers published on DBS, there has been no attempt at
Jeffrey D, Freeman, Lori M, Rosman, Jeremy D, Ratcliff, Paul T, Strickland, David R, Graham, Ellen K, Silbergeld   +5 more
openaire   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Dried blood spots: An evaluation of utility in the field

Journal of Infection and Public Health, 2018
Background: Use of dried blood spots (DBS) offers advantages over serum samples in studies conducted in resource-poor settings. The aim of this study was to compare the number of adequate spots collected across different demographic groups. Methods: Five
Xu Su, Bradley F. Carlson, Xiexiu Wang, Xiaoyan Li, Ying Zhang, JoLynn P. Montgomery, Yaxing Ding, Abram L. Wagner, Brenda Gillespie, Matthew L. Boulton   +9 more
doaj   +1 more source

A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method [PDF]

, 2016
BACKGROUND: The potential of microRNAs (miRNAs) as bedside biomarkers in selecting newborns with hypoxic-ischemic encephalopathy (HIE) for neuroprotection has yet to be explored. Commonly, blood-based biomarker tests use plasma or serum which don't allow
Adina Michael-Titus, AI Bartha, AJ Kole, AL Cardoso, B Buller, BH Walsh, Biomarkers Definitions Working Group., D Azzopardi, D Gazzolo, D Motti, Divyen K. Shah, DP Bartel, E Cherubini, E Huntzinger, Ellen Yip, EV Makeyev, G Long, Jane Evanson, JS McDonald, K Essandoh, K Page, L Liu, LF Chalak, LF Sempere, Liang-Fong Wong, M Jové, M Rutherford, MB Kirschner, NE Buroker, Olga Kapellou, P Gilje, P Leidinger, Ping K. Yip, R Sandhir, SK Patnaik, SM Lehmann, V Ramaswamy, Vennila Ponnusamy, X Cao, Y Li, Y Sun   +40 more
core   +3 more sources

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. [PDF]

, 2019
BackgroundNeonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of cytokines in neonates with brain injury are associated with acute symptomatic seizures or remote ...
Barkovich, A James, Deng, Xutao, Ferriero, Donna M, Foster-Barber, Audrey, Glass, Hannah C, Numis, Adam L, Rogers, Elizabeth E   +6 more
core  

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies [PDF]

, 2014
Biomarkers are directly-measured biological indicators of disease, health, exposures, or other biological information. In population and social sciences, biomarkers need to be easy to obtain, transport, and analyze.
Buxton, Orfeu M., Ostler, Michael W., Porter, James H.   +2 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Dried blood spots for qPCR diagnosis of acute Bartonella bacilliformis infection. [PDF]

, 2013
Bartonella bacilliformis is the etiological agent of a life-threatening illness. Thin blood smear is the most common diagnostic method for acute infection in endemic areas of Peru but remains of limited value because of low sensitivity.
Garcia, Patricia J, Mabey, David, Moore, David, Peeling, Rosanna W, Pérez-Lu, José E, Smit, Pieter W, Torres, Lorena L   +6 more
core   +1 more source