Results 141 to 150 of about 738,625 (360)

Caloric restriction delays age-related methylation drift

Nature Communications, 2017
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at ...
S. Maegawa, Yue Lu, T. Tahara, Justin T. Lee, J. Madzo, S. Liang, J. Jelinek, R. Colman, J. Issa   +8 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Business Process Drift [PDF]

, 2015
A synthetic dataset of 72 event logs based on Loan Assessment process, containing different types of process ...
Maaradji, A. (Abderrahmane), Dumas, M. (Marlon), La Rosa, M. (Marcello), Osctovar, A. (Alireza)   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effect of operational parameters on spray performance and drift characteristics of a UAV-based agrochemical application in pigeon pea crop to control thrips

Frontiers in Plant Science
In the past few years, UAV application in agriculture has increased significantly due to higher efficiency and safety, simple operation, reduced labor requirements, and saving chemicals as compared to conventional sprayers.
Gatkal N. R., Nalawade S. M., Shelke M. S., Deshmukh M. S., Bhanage G. B., More N. M., Ramesh K. Sahni, Marcel Mikeska   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mean drift forces on arrays of bodies due to incident long waves

, 1986
The scattering of long water waves by an array of bodies is investigated using the method of matched asymptotic expansions. Two particular geometries are considered, these are a group of vertical cylinders extending throughout the depth and a group of ...
McIver, P
core  

Characterization of frequency drift of sampled-grating DBR laser module under direct modulation [PDF]

, 2008
The authors demonstrate the drift in frequency of a static sampled-grating distributed Bragg reflector (SG DBR) laser module when it is subjected to direct modulation.
Anandarajah, Prince M., David McDonald, McDonald, David, Liam P. Barry, Prince M. Anandarajah, Aleksandra Kaszubowska-Anandarajah, Robert Maher, Barry, Liam P., Farrell, Tom, E. Connoly, Kaszubowska-Anandarajah, Aleksandra, Tom Farrell, Connolly, Eoin M., Maher, Robert D.   +13 more
core   +1 more source

Performance Evaluation of Simple Regular Buildings using FBD and DDBD Methods with a Consistent Target Drift

Civil Engineering Dimension
The Direct Displacement Based Design (DDBD) method, proposed by Priestley, is an alternative to the traditional Force-Based Design (FBD) method for earthquake-resistant design.
Pamuda Pudjisuryadi, William Sumargo, Alvin Kho, Benjamin Lumantarna   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source