Results 91 to 100 of about 930,869 (362)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Method to characterize directional changes in Arctic sea ice drift and associated deformation due to synoptic atmospheric variations using Lagrangian dispersion statistics [PDF]
The Cryosphere, 2017 A framework is developed to assess the directional changes in sea ice drift paths and associated deformation processes in response to atmospheric forcing.
J. V. Lukovich +2 more
doaj +1 more source
An Intercomparison of Satellite Derived Arctic Sea Ice Motion Products
Remote Sensing, 2022 Arctic sea ice motion information provides an important scientific basis for revealing the changing mechanism of Arctic sea ice and assessing the navigational safety of Arctic waterways. For now, many satellite derived Arctic sea ice motion products have
Xue Wang +5 more
doaj +1 more source
Agreement and Complementarity of Sea Ice Drift Products [PDF]
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2016 Changes in Arctic sea ice have raised questions about changes in sea ice drift patterns. Reduced sea ice coverage may open up the Arctic to further exploration of maritime activities, particularly during the summer months. Given such changes, it is important to investigate differences between available sea ice drift products.
Johansson, Malin, Berg, Anders
openaire +3 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
, 2017 We propose a satellite mission that uses a near-nadir Ka-band Doppler radar to measure surface currents, ice drift and ocean waves at spatial scales of 40 km and more, with snapshots at least every day for latitudes 75 to 82°, and every few days for ...
F. Ardhuin +29 more
semanticscholar +1 more source
Satellite-derived sea ice export and its impact on Arctic ice mass balance [PDF]
The Cryosphere, 2018 Sea ice volume export through the Fram Strait represents an important freshwater input to the North Atlantic, which could in turn modulate the intensity of the thermohaline circulation.
R. Ricker +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Soils of western Wright Valley, Antarctica [PDF]
, 2009 Western Wright Valley, from Wright Upper Glacier to the western end of the Dais, can be divided into three broad geomorphic regions: the elevated Labyrinth, the narrow Dais which is connected to the Labyrinth, and the North and South forks which are ...
Aislabie, Jackie M. +3 more
core +2 more sources