Results 101 to 110 of about 930,869 (362)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Journal of Glaciology, 2020 On 29 April 2015, four beacons were deployed onto an ice island in the Strait of Belle Isle to record positional data. The ice island later broke up into many fragments, four of which were tracked by the beacons.
Reza Zeinali Torbati +3 more
doaj +1 more source
Sea ice drift tracks from autonomous buoys in the MOSAiC Distributed Network
Scientific Data, 2023 A network of autonomous, ice-tethered buoys was deployed around the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) experiment in late September 2019 for a year-long drift in the Arctic Transpolar Drift Stream.
Angela C. Bliss +2 more
doaj +1 more source
Assimilation of sea surface temperature, sea ice concentration and sea ice drift in a model of the Southern Ocean [PDF]
, 2015 Current ocean models have relatively large errors and biases in the Southern Ocean. The aim of this study is to provide a reanalysis from 1985 to 2006 assimilating sea surface temperature, sea ice concentration and sea ice drift.
Alvera-Azcárate, Aida +8 more
core +5 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Higher-order statistical moments to analyse Arctic sea-ice drift patterns
Annals of Glaciology, 2020 Geophysical systems are often assumed to follow Gaussian probability density functions; however, deviations from Gaussian behaviour can shed light on the underlying dynamics.
Satwant Kaur +3 more
doaj +1 more source
Impact of the ice strength formulation on the performance of a sea ice thickness distribution model in the Arctic [PDF]
, 2017 The impact of a subgrid-scale ice thickness distribution (ITD) and two standard ice strength formulations on simulated Arctic sea ice climate is investigated.
Losch, Martin +3 more
core +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Regime characteristics and patterns of the sea ice drift on the shelf at Magadan in the Okhotsk Sea
Известия ТИНРО, 2016 The sea ice characteristics and drift patterns are considered for the Okhotsk Sea shelf at Magadan on retrospective data of the ice observations and satellite images. Spatial heterogeneity of the sea ice parameters and its drift is shown.
Vladimir V. Plotnikov +3 more
doaj +1 more source