Results 71 to 80 of about 24,976 (288)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Air–Ice–Ocean Momentum Exchange. Part II: Ice Drift
Journal of Physical Oceanography, 1997 A model was constructed to estimate ice floe trajectories. The model considers the balance of atmosphere and ocean drag forces on ice floes, including skin and body drag forces from wind, waves, and currents. Discussion of air‐ice and water‐ice skin stresses, water‐ice form stress, and wave radiation stress is presented. Estimates are presented for the
Will Perrie, Yongcun Hu
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Remote Sensing, 2018 We studied two issues to be considered in the calculation of parameters characterizing sea ice deformation: the effect of uncertainties in an automatically retrieved sea ice drift field, and the influence of the type of drift vector grid.
Jakob Griebel, Wolfgang Dierking
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Method to Improve High-Resolution Sea Ice Drift Retrievals in the Presence of Deformation Zones
Remote Sensing, 2017 Retrievals of sea ice drift from synthetic aperture radar (SAR) images at high spatial resolution are valuable for understanding kinematic behavior and deformation processes of the ice at different spatial scales.
Jakob Griebel, Wolfgang Dierking
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
International Journal of Digital EarthAccurate monitoring of sea ice drift has become increasingly crucial for climate research and safe navigation in polar regions. Existing sea ice drift extraction methods based on passive microwave data utilize single-frequency data, which have ...
Peng Jiang +4 more
doaj +1 more source