Results 121 to 130 of about 638,433 (245)
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Prospectus & Mitigation Plan Two Yutes Wetland Mitigation Bank LRB-2024-00296 Hilldom Road, Monroe Township, Ashtabula County, Ohio May 2025 Prepared by: Davey Mitigation 717 N.
Davey Mitigation; Davey Resource Group Inc.;
core
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Adaptation, Mitigation and Risk-Taking in Climate Policy [PDF]
The future consequences of climate change are highly uncertain. Today, the exact size of possible future damages are widely unknown. Governments try to cope with these risks by investing in mitigation and adaptation measures.
Kai A. Konrad +2 more
core
AgronomyIn dense or structurally complex canopies, spray applications often fail to adequately reach the specific plant sites where pest organisms reside, typically the lower canopy and abaxial leaf surfaces. An additional challenge is balancing drift mitigation
Ingrid Zwertvaegher +6 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
LLM Output Drift: Cross-Provider Validation & Mitigation for Financial Workflows
CoRRFinancial institutions deploy Large Language Models (LLMs) for reconciliations, regulatory reporting, and client communications, but nondeterministic outputs (output drift) undermine auditability and trust. We quantify drift across five model architectures (7B-120B parameters) on regulated financial tasks, revealing a stark inverse relationship ...
Raffi Khatchadourian, Rolando Franco
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han +8 more
wiley +1 more source
, 2010 We present recent progress from the DRIFT (Directional Recoil Identification From Tracks) collaboration. We summarise recent work demonstrating 1) directional sensitivity to a neutron source in a 1m3 DRIFT-II detector in all 3 dimensions at energies of ...
Pipe, M +2 more
core +1 more source