Results 111 to 120 of about 638,433 (245)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Use of the Extended Kalman Filter for State Dependent Drift Estimation in Weakly Nonlinear Sensors

, 2006
A number of mechanisms are responsible for the generation of reversible or irreversible drift in the response of a sensor. In this letter, we discuss three approaches for the identification of reversible state dependent drift in sensors through the use ...
White, Neil M., Harris, Chris J., Karatzas, Dimosthenis, Chorti, Arsenia   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Davey Mitigation, Two Yutes mitigation banking instrument, LRB-2024-00296

1 DAVEY MITIGATION TWO YUTES MITIGATION BANKING INSTRUMENT, LRB-2024-00296 This Mitigation Banking Instrument (the “Instrument”), established consistent with 33 CFR 332.8, describes the establishment, use, operation, and maintenance of the DAVEY ...
Davey Mitigation;
core  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Oregon NHMP [PDF]

, 2015
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on April 15, 2015).Mode of ...

core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Benefit-Cost Analysis of FEMA Hazard Mitigation Grants [PDF]

Mitigation ameliorates the impact of natural hazards on communities by reducing loss of life and injury, property and environmental damage, and social and economic disruption.
John C. Whitehead, Charles Huyck, Jawhar Bouabid, Ronald T. Eguchi, Carol Taylor West, Craig Taylor, Douglass Shaw, Anne S. Kiremidjian, L. Thomas Tobin, Keith Porter, Nicole Dash, Thomas R. McLane, Adam Rose, David Godschalk, Philip T. Ganderton, Kathleen   +15 more
core  

Enhancing accuracy and convenience of golf swing tracking with a wrist-worn single inertial sensor

Scientific Reports
In this study, we address two technical challenges to enhance golf swing trajectory accuracy using a wrist-worn inertial sensor: orientation estimation and drift error mitigation.
Myeongsub Kim, Sukyung Park
doaj   +1 more source