Results 91 to 100 of about 638,433 (245)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

GeoGNN: Quantifying and Mitigating Semantic Drift in Text-Attributed Graphs

CoRR
Graph neural networks (GNNs) on text--attributed graphs (TAGs) typically encode node texts using pretrained language models (PLMs) and propagate these embeddings through linear neighborhood aggregation. However, the representation spaces of modern PLMs are highly non--linear and geometrically structured, where textual embeddings reside on curved ...
Liangwei Yang, Jing Ma 0004, Jianguo Zhang 0005, Zhiwei Liu 0001, Jielin Qiu, Shirley Kokane, Shiyu Wang, Haolin Chen, Rithesh Murthy, Ming Zhu, Huan Wang 0016, Weiran Yao, Caiming Xiong, Shelby Heinecke   +13 more
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Mitigating Resolution-Drift in Federated Learning: Case of Keypoint Detection

CoRR
The Federated Learning (FL) approach enables effective learning across distributed systems, while preserving user data privacy. To date, research has primarily focused on addressing statistical heterogeneity and communication efficiency, through which FL has achieved success in classification tasks. However, its application to non-classification tasks,
Taeheon Lim, Joohyung Lee, Kyungjae Lee 0001, Jungchan Cho   +3 more
openaire   +3 more sources

Anticipating Vehicle Drift in the Real-World: A Data-Driven Intelligence Layer for Future AVs

IEEE Access
Extreme driving scenarios, such as drifting, pose significant risks to driving safety. This article proposes a novel intelligence layer for vehicle drift detection, characterisation and anticipation, fostering the development of Advanced Driver ...
Ines Rito Lima, Yukie Nagai, Jose Santos-Victor   +2 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Implications of a lowered damage trajectory for mitigation in a continuous-time stochastic model [PDF]

This paper provides counterexamples to the idea that mitigation of greenhouse gases causing climate change, and adaptation to climate change, are always and everywhere substitutes.
Strand, Jon
core  

Comparison of Environmental Risk Indices Related to Pesticide Spray Drift in Extensive Agriculture in Uruguay

Agrociencia Uruguay
Pesticide spray drift is an off-target pathway in extensive cropping systems that can lead to the exposure of non-target organisms and nearby human populations.
Winnona Saracho, Isabel García, João Paulo Arantes Rodrigues da Cunha, Juana Villalba   +3 more
doaj   +1 more source