Results 81 to 90 of about 638,433 (245)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Concepts of Drift and Selection in “The Great Snail Debate” of the 1950s and Early 1960s [PDF]
, 2007 Recently, much philosophical discussion has centered on the best way to characterize the concepts of random drift and natural selection, and, in particular, on the question of whether selection and drift can be conceptually distinguished (Beatty 1984 ...
Millstein, Roberta L.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Bio-Efficiency of Foliar Herbicides Applied with Drift-Reducing Nozzles
AgricultureThe increasing implementation of drift-reduction regulations in agriculture has driven the widespread adoption of drift-reducing spray nozzles.
Sander De Ryck +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
German Regulation – Drift Modelling
, 2004 The application of plant protection products is associated with the unavoidable occurrence of direct drift. The volume of transported and deposited drops is influenced by prevailing technical, technological, and meteorological conditions.
Moll, Eckhard +3 more
core
Debris Mitigation Methods for Bridge Piers, Final Repory, June 2012 [PDF]
, 2012 Debris accumulation on bridge piers is an on-going national problem that can obstruct the waterway openings at bridges and result in significant erosion of stream banks and scour at abutments and piers.
core
The Kansas Hazard Mitigation Strategy
, 2002 Rev. 2.; application/pdf; "January 2002.""This document is a comprehensive strategy developed by the state agencies of Kansas to create an effective, long-term approach to eliminate or reduce the vulnerability of Kansas' communities to the human ...
Kansas Hazard Mitigation Team.
core +1 more source
Toward Generalizable mmWave and Terahertz Deep Learning-Based Channel Prediction in 6G Networks
IEEE Open Journal of the Communications SocietyThe use of millimeter-wave (mmWave) and Terahertz (THz) bands is essential for 6G networks, as they enable ultra-high data rates, increased capacity, and low-latency communication, thereby enabling transformative applications from virtual reality to ...
Eslam Hasan +5 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source