A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong +17 more
wiley +1 more source
Heavy metal contamination and remediation in deep drilling across Chinese energy basins. [PDF]
Liu Y, Guo W, Wu Y, Guo W.
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Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
Modeling and optimizing the delamination factor in Agave americana L. biowaste fiber-reinforced biocomposite drilling: a study using RSM and ANN methods. [PDF]
Lalaymia I +6 more
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Organic-Inorganic Hybrid Gel Microspheres as a Plugging Agent for Ultra-High Temperature and High-Salinity Water-Based Drilling Fluids. [PDF]
Sun Y, Sun J, Lv K, Huang X, Liu J.
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Intelligent optimization of micro-electrical discharge machining of aluminum nitride ceramics using nano abrasive zirconium oxide-enhanced biodegradable dielectric. [PDF]
Ravi M +5 more
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Drilling Characteristics of Additively Manufactured PLA/17-4 PH Stainless Steel Hybrid Composite: Thrust Force, Surface Roughness, Vibration and Temperature Change. [PDF]
Şentürk E +4 more
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Quadri-Wave Lateral Shearing Interferogram Outpainting Using QW-GAN for Accurate Wavefront Reconstruction. [PDF]
Fan Y, Duan Y, Zhang Y, Da Z, Yue Y.
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Research and application of quantitative model for optimal well trajectory selection. [PDF]
Xiao Y +6 more
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Evaluation of coupled machine learning models for drilling optimization
Journal of Natural Gas Science and Engineering, 2018Drilling optimization can provide significant value to an oil and gas project, especially in a low-price environment. This is generally approached by optimizing the rate of penetration (ROP) of the well, which may not always be the best strategy.
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