Results 161 to 170 of about 2,261,771 (384)

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Drinking Water Quality Management for Broiler Performance and Carcass Characteristics

World
Objective: This study aimed to assess the impact of water quality as determined by its physical, chemical, and biological composition collected from five distinct points in Maragheh, Iran, on the performance and carcass traits of Ross-308 commercial ...
Naser Amir Ebrahimi, Ali Nobakht, Hakan İnci, Valiollah Palangi, Marian Suplata, Maximilian Lackner   +5 more
doaj   +1 more source

Are Alcohol Excise Taxes Good For Us? Short and Long-Term Effects on Mortality Rates [PDF]

Regression results from a 30-year panel of the state-level data indicate that changes in alcohol-excise taxes cause a reduction in drinking and lower all-cause mortality in the short run.
Frank A. Sloan, Jan Ostermann, Philip J. Cook   +2 more
core  

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

The AUDIT Alcohol consumption questions (AUDIT-C) : An effective brief screening test for problem drinking

, 1998
K. Bush, D. Kivlahan, M. McDonell, S. Fihn, K. Bradley   +4 more
semanticscholar   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Negative Correlation Between Vitamin A and Positive Correlation Between Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2018 7th Edition

Journal of Inflammation Research, 2020
Ki-Hong Hong,1 Young Lee2 1Department of Family Medicine, Nursing Hospital, Seoul Veterans Hospital, Seoul 05368, Republic of Korea; 2Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of ...
Hong KH, Lee Y
doaj  

2010 Anchorage Underage Drinking Survey: A Look at Adult Attitudes, Perceptions, and Norms [PDF]

, 2012
The Anchorage Underage Drinking Survey (AUDS) was conducted to assess adults’ recent exposure to Communities Mobilizing for Change on Alcohol media campaign about underage drinking, as well as adult attitudes, norms, and perceptions regarding the ...
McMullen, Jennifer, Parker, Khristy, Rivera, Marny   +2 more
core  

Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response

, 2019
Katie Witkiewitz, Corey R. Roos, Karl Mann, Henry R. Kranzler   +3 more
openalex   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source